Clinical high risk for psychosis

• Verfasst von: Rietschel, Liz [VerfasserIn]
• Verfasst von: Zink, Mathias [VerfasserIn]
• Titel: Clinical high risk for psychosis
• Titelzusatz: gender differences in symptoms and social functioning
• Verf.angabe: Liz Rietschel, Martin Lambert, Anne Karow, Mathias Zink, Hendrik Müller, Andreas Heinz, Walter de Millas, Birgit Janssen, Wolfgang Gaebel, Frank Schneider, Dieter Naber, Georg Juckel, Seza Krüger‐Özgürdal, Thomas Wobrock, Michael Wagner, Wolfgang Maier, Joachim Klosterkötter and Andreas Bechdolf for the PREVENT study group
• Jahr: 2017
• Jahr des Originals: 2015
• Umfang: 8 S.
• Fussnoten: First published: 24 March 2015 ; Gesehen am 12.07.2018 ; First published: 24 March 2015
• Titel Quelle: Enthalten in: Early intervention in psychiatry
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 2007
• Jahr Quelle: 2017
• Band/Heft Quelle: 11(2017), 4, Seite 306-313
• ISSN Quelle: 1751-7893
• DOI: doi:10.1111/eip.12240
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: gender
• Sach-SW: negative symptom
• Sach-SW: prodrome
• Sach-SW: psychosis
• Sach-SW: social functioning
• K10plus-PPN: 1577559819

Abstract

Aim: Schizophrenia is a heterogeneous disorder that presents differently in men and women: men show a higher propensity to negative symptoms, lower social functioning, earlier age at onset and co-morbid substance abuse, whereas women display more affective symptoms. It is unknown whether these differences extend to subjects at high risk (HR) of psychosis. Thus, the aim of the present study was to address this question. Methods: Clinical symptoms and functioning were assessed using structured interviews in 239 HR subjects (female, n = 80). The definition of being at HR was based on the criteria used in the European Prediction of Psychosis Study (EPOS). Results: Men displayed more pronounced negative symptoms, higher rates of past substance abuse disorders and higher deficits in social functioning. No gender difference was found for depression, which affected almost 50% of the cohort, or age at onset for the fulfilment of HR criteria. Conclusion: The higher impairment in specific symptoms observed in male schizophrenia patients was also present in subjects at HR for psychosis. Further studies are required to determine whether these symptoms are gender-specific predictors of transition to psychosis and whether they warrant gender-specific interventions. The high propensity to depression in the present cohort, which was particularly pronounced in the male cohort compared with the general population, in conjunction with the observed increase in negative symptoms and functional impairment, should alert clinicians to the necessity for the identification and treatment of HR subjects, irrespective of the degree to which these features are associated with transition risk.