Glycogen synthase kinase is a regulator of the circadian clock of Neurospora crassa

• Verfasst von: Tataroglu, Ozgur [VerfasserIn]
• Verfasst von: Lauinger, Linda [VerfasserIn]
• Verfasst von: Sancar, Gencer [VerfasserIn]
• Verfasst von: Brunner, Michael [VerfasserIn]
• Verfasst von: Diernfellner, Axel [VerfasserIn]
• Titel: Glycogen synthase kinase is a regulator of the circadian clock of Neurospora crassa
• Verf.angabe: Özgür Tataroğlu, Linda Lauinger, Gencer Sancar, Katharina Jakob, Michael Brunner, and Axel C.R. Diernfellner
• Umfang: 9 S.
• Fussnoten: Gesehen am 13.07.2018
• Titel Quelle: Enthalten in: The journal of biological chemistry
• Jahr Quelle: 2012
• Band/Heft Quelle: 287(2012), 44, S. 36936-36943
• ISSN Quelle: 1083-351X
• DOI: doi:10.1074/jbc.M112.396622
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577576667

Abstract

Timekeeping by circadian clocks relies upon precise adjustment of expression levels of clock proteins. Here we identify glycogen synthase kinase (GSK) as a novel and critical component of the circadian clock of Neurospora crassa that regulates the abundance of its core transcription factor white collar complex (WCC) on a post-transcriptional level. We show that GSK specifically binds and phosphorylates both subunits of the WCC. Reduced expression of GSK promotes an increased accumulation of WC-1, the limiting factor of the WCC, causing an acceleration of the circadian clock and a shorter free-running period.