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Verfasst von:Feuerecker, Matthias S. [VerfasserIn]   i
 Thiel, Manfred [VerfasserIn]   i
Titel:Effects of exercise stress on the endocannabinoid system in humans under field conditions
Verf.angabe:M. Feuerecker, D. Hauer, R. Toth, F. Demetz, J. Hölzl, M. Thiel, I. Kaufmann, G. Schelling, A. Choukèr
Jahr:2012
Jahr des Originals:2011
Umfang:5 S.
Fussnoten:Gesehen am 16.07.2018 ; Published online first: 19 November 2011
Titel Quelle:Enthalten in: European journal of applied physiology
Ort Quelle:Berlin : Springer, 1928
Jahr Quelle:2012
Band/Heft Quelle:112(2012), 7, Seite 2777-2781
ISSN Quelle:1439-6327
 1432-1025
Abstract:The effects of physical exercise stress on the endocannabinoid system in humans are almost unexplored. In this prospective study, we investigated in a crossover design and under field conditions at different altitudes the effects of physical exercise on the endocannabinoid system (ECS) in 12 trained healthy volunteers. For determination of alterations on the ECS three different protocols were analyzed: Protocol A (physical exercise at lower altitude) involved strenuous hiking below 2,100 m, whereas Protocol B (physical exercise by active ascent to high altitude) involved hiking up to 3,196 m, an accommodation at the cottage and a descent the next day. Protocol C (passive ascent) included a helicopter ascent to 3,196 m, an overnight stay at this altitude and a flight back to the base camp the following day. The cumulative hiked altitude in Protocol A and B was comparable (~1,650 m). The blood EC concentrations of anandamide increased significantly in Protocol A/B from baseline (T0) 0.12 ± 0.01/0.16 ± 0.02 (mean ± SEM) to 0.27 ± 0.02/0.42 ± 0.02 after exercise (T1) (p < 0.05). Anandamide levels in Protocol C remained stable at 0.20 ± 0.02. We conclude that the ECS is activated upon strenuous exercise whereas the combination with hypoxic stress further increases its activity. The reduced partial pressure of oxygen at high altitude alone did not affect this system. In summary, physical exercise activates the endocannabinoid system, whereas the combination with high altitude enhances this activation. This discloses new perspectives to adaptation mechanisms to physical exercise.
DOI:doi:10.1007/s00421-011-2237-0
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://link.springer.com/article/10.1007/s00421-011-2237-0
 Volltext: http://dx.doi.org/10.1007/s00421-011-2237-0
 DOI: https://doi.org/10.1007/s00421-011-2237-0
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577608046
Verknüpfungen:→ Zeitschrift

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