Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients

• Verfasst von: Esslinger, Christine [VerfasserIn]
• Verfasst von: Inta, Dragos [VerfasserIn]
• Verfasst von: Kirsch, Peter [VerfasserIn]
• Verfasst von: Meyer-Lindenberg, Andreas [VerfasserIn]
• Verfasst von: Zink, Mathias [VerfasserIn]
• Titel: Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients
• Verf.angabe: Christine Esslinger, Susanne Englisch, Dragos Inta, Franziska Rausch, Frederike Schirmbeck, Daniela Mier, Peter Kirsch, Andreas Meyer-Lindenberg, Mathias Zink
• E-Jahr: 2012
• Jahr: 10 July 2012
• Umfang: 8 S.
• Fussnoten: Gesehen am 16.07.2018 ; Available online 10 July 2012
• Titel Quelle: Enthalten in: Schizophrenia research
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1988
• Jahr Quelle: 2012
• Band/Heft Quelle: 140(2012), 1-3, Seite 114-121
• ISSN Quelle: 1573-2509
• DOI: doi:10.1016/j.schres.2012.06.025
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: First episode
• Sach-SW: Functional magnetic imaging
• Sach-SW: Reward
• Sach-SW: Salience
• Sach-SW: Schizophrenia
• Sach-SW: Ventral striatum
• K10plus-PPN: 1577613058

Abstract

Patients with schizophrenia show deficits in motivation, reward anticipation and salience attribution. Several functional magnetic resonance imaging (fMRI) investigations revealed neurobiological correlates of these deficits, raising the hypothesis of a common basis in midbrain dopaminergic signaling. However, investigations of drug-naïve first-episode patients with comprehensive fMRI tasks are still missing. We recruited unmedicated schizophrenia spectrum patients (N=27) and healthy control subjects (N=27) matched for sex, age and educational levels. An established monetary reward anticipation task in combination with a novel task aiming at implicit salience attribution without the confound of monetary incentive was applied. Patients showed reduced right ventral striatal activation during reward anticipation. Furthermore, patients with a more pronounced hypoactivation attributed more salience to neutral stimuli, had more positive symptoms and better executive functioning. In the patient group, a more differentially active striatum during reward anticipation was correlated positively to differential ventral striatal activation in the implicit salience attribution task. In conclusion, a deficit in ventral striatal activation during reward anticipation can already be seen in drug-naïve, first episode schizophrenia patients. The data suggest that rather a deficit in differential ventral striatal activation than a generally reduced activation underlies motivational deficits in schizophrenia and that this deficit is related to the aberrant salience attribution.