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Verfasst von:Sevko, Alexandra [VerfasserIn]   i
 Kremer, Veronika [VerfasserIn]   i
 Umansky, Ludmila [VerfasserIn]   i
 Umansky, Viktor [VerfasserIn]   i
Titel:Application of paclitaxel in low non-cytotoxic doses supports vaccination with melanoma antigens in normal mice
Verf.angabe:Alexandra Sevko, Veronika Kremer, Christine Falk, Ludmila Umansky, Michael R. Shurin, Galina V. Shurin and Viktor Umansky
E-Jahr:2012
Jahr:27 Mar 2012
Umfang:7 S.
Fussnoten:Published online: 27 Mar 2012 ; Gesehen am 16.07.2018
Titel Quelle:Enthalten in: Journal of immunotoxicology
Ort Quelle:London [u.a.] : Taylor and Francis Group, 2004
Jahr Quelle:2012
Band/Heft Quelle:9(2012), 3, Seite 275-281
ISSN Quelle:1547-6901
Abstract:Chemotherapeutic agents such as paclitaxel applied in ultra-low, non-cytotoxic doses were previously shown to stimulate dendritic cell activity and anti-tumor immune responses upon vaccination in mouse transplantable tumor models. However, the mechanisms of these alterations-termed chemoimmunomodulation or chemomodulation-are still not clear. This study investigated the effect of paclitaxel applied in ultra-low, non-cytotoxic doses on the efficiency of immunization of healthy C57BL/6 mice with the peptide derived from tyrosinase related protein (TRP)-2 as a model melanoma antigen. Using an IFNγ ELISPOT assay, it was found that administration of 1 mg paclitaxel/kg in combination with the peptide vaccination strongly increased the frequencies of TRP-2 specific spleen T-cells as compared to levels due to the vaccination alone. This was associated with a significant decrease in the levels of regulatory T-cells (Treg) and immature myeloid cells (known as a counterpart of myeloid derived suppressor cells [MDSC] in healthy mice). Such impairments of potential immunosuppressive cells were found to correlate with a strong increase in the amount of effector CD8+ and CD4+ T-cells in the bone marrow and spleen. Furthermore, in paclitaxel-treated mice, a significant augmentation of natural killer (NK) cell numbers in the bone marrow and their ability to produce IFNγ were observed. In addition, the level of NK-T-cells in the lymph nodes was also increased. It is suggested that paclitaxel applied in ultra-low, non-cytotoxic doses may potentially enhance the efficacy of anti-tumor vaccinations by neutralizing immunosuppressive Treg and MDSC populations in tumor-bearing hosts.
DOI:doi:10.3109/1547691X.2012.655343
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.3109/1547691X.2012.655343
 kostenfrei: Volltext: https://doi.org/10.3109/1547691X.2012.655343
 DOI: https://doi.org/10.3109/1547691X.2012.655343
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chemoimmunomodulation
 immature myeloid cells
 myeloid-derived suppressor cells
 Non-cytotoxic chemotherapy
 paclitaxel
 peptide immunization
 regulatory T-cells
K10plus-PPN:1577643259
Verknüpfungen:→ Zeitschrift

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