Breathlessness and restrictive lung disease

• Verfasst von: Kopf, Stefan [VerfasserIn]
• Verfasst von: Gröner, Jan [VerfasserIn]
• Verfasst von: Kender, Zoltán [VerfasserIn]
• Verfasst von: Fleming, Thomas [VerfasserIn]
• Verfasst von: Brune, Maik [VerfasserIn]
• Verfasst von: Riedinger, Christin [VerfasserIn]
• Verfasst von: Volk, Nadine [VerfasserIn]
• Verfasst von: Herpel, Esther [VerfasserIn]
• Verfasst von: Wielpütz, Mark Oliver [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Katus, Hugo [VerfasserIn]
• Verfasst von: Kreuter, Michael [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Titel: Breathlessness and restrictive lung disease
• Titelzusatz: an important diabetes-related feature in patients with type 2 diabetes
• Verf.angabe: Stefan Kopf, Jan B. Groener, Zoltan Kender, Thomas Fleming, Maik Brune, Christin Riedinger, Nadine Volk, Esther Herpel, Dominik Pesta, Julia Szendrödi, Mark O. Wielpütz, Hans-Ulrich Kauczor, Hugo A. Katus, Michael Kreuter, Peter P. Nawroth
• E-Jahr: 2018
• Jahr: June 06, 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 17.07.2018
• Titel Quelle: Enthalten in: Respiration
• Ort Quelle: Basel : Karger, 1944
• Jahr Quelle: 2018
• Band/Heft Quelle: 96(2018), 1, Seite 29-40
• ISSN Quelle: 1423-0356
• DOI: doi:10.1159/000488909
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 157765112X

Abstract

<b><i>Background:</i></b> Diabetes mellitus is a significant comorbidity of interstitial lung disease (ILD). <b><i>Objectives:</i></b> The aim of this study was to investigate the incidence of restrictive lung disease (RLD) and ILD in patients with prediabetes and type 2 diabetes (T2D). <b><i>Methods:</i></b> Forty-eight nondiabetics, 68 patients with prediabetes, 29 newly diagnosed T2D, and 110 patients with long-term T2D were examined for metabolic control, diabetes-related complications, breathlessness, and lung function. Five participants with T2D, breathlessness, and RLD underwent multidetector computed tomography (MDCT) and a Six-Minute Walk Test (6MWT). Lung tissue from 4 patients without diabetes and from 3 patients with T2D was histologically examined for presence of pulmonary fibrosis. <b><i>Results:</i></b> Breathlessness in combination with RLD was significantly increased in patients with prediabetes and T2D (<i>p</i> &#x3c; 0.01). RLD was found in 9% of patients with prediabetes, in 20% of patients with newly diagnosed T2D, and in 27% of patients with long-term T2D. Thus, patients with long-term T2D had an increased risk of RLD (OR 5.82 [95% CI 1.71-20.5], <i>p</i> &#x3c; 0.01). RLD was significantly associated with glucose metabolism and albuminuria (<i>p</i> &#x3c; 0.01); furthermore, presence of nephropathy increased the risk of RLD (OR 8.57 [95% CI 3.4-21.9], <i>p</i> &#x3c; 0.01) compared to nondiabetics. MDCT revealed ILD in 4 patients, the 6MWT correlated with the extent of ILD, and histological analysis showed fibrosing ILD in patients with T2D. <b><i>Conclusions:</i></b> This study demonstrates increased breathlessness and a high prevalence of RLD in patients with T2D, indicating an association between diabetes and fibrosing ILD.