Critical evaluation of mouse models used to study pain and loss of pain perception in diabetic neuropathy

• Verfasst von: Bierhaus, Angelika [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Titel: Critical evaluation of mouse models used to study pain and loss of pain perception in diabetic neuropathy
• Verf.angabe: A. Bierhaus, P. P. Nawroth
• E-Jahr: 2012
• Jahr: 08. März 2012
• Umfang: 3 S.
• Fussnoten: Publikationsdatum: 08. März 2012 (eFirst) ; Gesehen am 17.07.2017
• Titel Quelle: Enthalten in: Experimental and clinical endocrinology & diabetes
• Ort Quelle: Stuttgart [u.a.] : Thieme, 1983
• Jahr Quelle: 2012
• Band/Heft Quelle: 120(2012), 4, Seite 188-190
• ISSN Quelle: 1439-3646
• DOI: doi:10.1055/s-0032-1304567
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577651316

Abstract

A number of studies have addressed diabetic neuropathy (DN) in transgenic and knock out mouse models to unravel the molecular mechanisms underlying metabolic pain and loss of pain perception. However, it is difficult to compare these studies with each other or even with human DN due to experimental differences including the type of diabetes, the background strain of the respective mouse model, the methods of diabetes induction and the duration of diabetes, animal age and gender. To receive useful information for DN from genetically modified mice, it is therefore mandatory to first define the appropriate model and - if necessary - to backcross transgenic strains into the respective background to allow a reliable (and at least in part translatable to human DN) interpretation of the results.