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Verfasst von:Hirjak, Dusan [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
 Kubera, Katharina Maria [VerfasserIn]   i
 Thomann, Anne K. [VerfasserIn]   i
 Maier-Hein, Klaus H. [VerfasserIn]   i
 Schröder, Johannes [VerfasserIn]   i
 Thomann, Philipp [VerfasserIn]   i
Titel:Cortical signature of clock drawing performance in Alzheimer's disease and mild cognitive impairment
Verf.angabe:Dusan Hirjak, Robert C. Wolf, Barbara Pfeifer, Katharina M. Kubera, Anne K. Thomann, Ulrich Seidl, Klaus H. Maier-Hein, Johannes Schröder, Philipp A. Thomann
E-Jahr:2017
Jahr:July 2017
Umfang:10 S.
Fussnoten:Gesehen am 17.07.2018
Titel Quelle:Enthalten in: Journal of psychiatric research
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1961
Jahr Quelle:2017
Band/Heft Quelle:90(2017), Seite 133-142
ISSN Quelle:1879-1379
Abstract:It is unclear whether clock drawing test (CDT) performance relies on a widely distributed cortical network, or whether this test predominantly taps into parietal cortex function. So far, associations between cortical integrity and CDT impairment in Alzheimer's disease (AD) and mild cognitive impairment (MCI) largely stem from cortical volume analyses. Given that volume is a product of thickness and surface area, investigation of the relationship between CDT and these two cortical measures might contribute to better understanding of this cognitive screening tool for AD. 38 patients with AD, 38 individuals with MCI and 31 healthy controls (HC) underwent CDT assessment and MRI at 3 Tesla. The surface-based analysis via Freesurfer enabled calculation of cortical thickness and surface area. CDT was scored according to the method proposed by Shulman and related to the two distinct cortical measurements. Higher CDT scores across the entire sample were associated with cortical thickness in bilateral temporal gyrus, the right supramarginal gyrus, and the bilateral parietal gyrus, respectively (p < 0.001 CWP corr.). Significant associations between CDT and cortical thickness reduction in the parietal lobe remained significant when analyses were restricted to AD individuals. There was no statistically significant association between CDT scores and surface area (p < 0.001 CWP corr.). In conclusion, CDT performance may be driven by cortical thickness alterations in regions previously identified as “AD vulnerable”, i.e. regions predominantly including temporal and parietal lobes. Our results suggest that cortical features of distinct evolutionary and genetic origin differently contribute to CDT performance.
DOI:doi:10.1016/j.jpsychires.2017.02.019
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.jpsychires.2017.02.019
 Volltext: http://www.sciencedirect.com/science/article/pii/S0022395616305945
 DOI: https://doi.org/10.1016/j.jpsychires.2017.02.019
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Alzheimer's disease
 Clock drawing test
 Freesurfer
 Mild cognitive impairment
 MRI
K10plus-PPN:1577664191
Verknüpfungen:→ Zeitschrift

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