Duration of type 2 diabetes strongly predicts all-cause and cardiovascular mortality in people referred for coronary angiography

• Verfasst von: Silbernagel, Günther [VerfasserIn]
• Verfasst von: Grammer, Tanja B. [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Duration of type 2 diabetes strongly predicts all-cause and cardiovascular mortality in people referred for coronary angiography
• Verf.angabe: Guenther Silbernagel, Silke Rosinger, Tanja B. Grammer, Marcus E. Kleber, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried März
• E-Jahr: 2012
• Jahr: 11 January 2012
• Umfang: 7 S.
• Fussnoten: Available online 11 January 2012
• Titel Quelle: Enthalten in: Atherosclerosis
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1970
• Jahr Quelle: 2012
• Band/Heft Quelle: 221(2012), 2, Seite 551-557
• ISSN Quelle: 1879-1484
• DOI: doi:10.1016/j.atherosclerosis.2012.01.011
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: All-cause mortality
• Sach-SW: Cardiovascular mortality
• Sach-SW: Duration of type 2 diabetes
• K10plus-PPN: 1577724054

Abstract

Objective - Type 2 diabetes represents a major cardiovascular risk factor. However, few studies have addressed the impact of the disease duration on mortality. Thus, we aimed to investigate the predictive value of diabetes duration for all-cause and cardiovascular mortality in subjects undergoing coronary angiography. - Methods - We studied 2455 participants of the LUdwigshafen RIsk and Cardiovascular health study (1768 males/687 females). They had a mean±standard deviation (SD) age of 63.1±9.0 years (range: 40.0-79.9) and a mean±SD body mass index of 27.7±4.0kg/m2. 704 subjects were newly diagnosed with type 2 diabetes according to the 2010 criteria of the American Diabetes Association and 446 subjects had a known history of type 2 diabetes. The mean±SD duration of the follow-up for all-cause and cardiovascular mortality was 7.4±2.3 years. - Results - A total of 543 deaths occurred during the follow-up. Among these, 343 were accounted for by cardiovascular diseases. The duration of type 2 diabetes was strongly and positively correlated with all-cause and cardiovascular mortality (both P<0.001). The multivariate adjusted hazard ratios (95% confidence intervals) for cardiovascular mortality compared to subjects without diabetes were 1.76 (1.34-2.32), 2.86 (2.00-4.08), 2.96 (1.85-4.74), and 4.55 (3.24-6.39) for subjects with new onset type 2 diabetes and subjects with known type 2 diabetes (duration ≤5, >5 and ≤10, >10 years), respectively. - Conclusions - The data emphasise the need to consider the diabetes duration for the prediction of mortality in subjects at intermediate to high cardiovascular risk.