Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization

• Verfasst von: Heiß, Kirsten [VerfasserIn]
• Verfasst von: Maier, Marion Irmgard [VerfasserIn]
• Verfasst von: Hoffmann, Angelika [VerfasserIn]
• Verfasst von: Frank, Roland [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Müller, Ann-Kristin [VerfasserIn]
• Verfasst von: Pfeil, Johannes [VerfasserIn]
• Titel: Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
• Verf.angabe: Kirsten Heiss, Marion Irmgard Maier, Angelika Hoffmann, Roland Frank, Martin Bendszus, Ann-Kristin Mueller & Johannes Pfeil
• E-Jahr: 2018
• Jahr: 15 February 2018
• Umfang: 10 S.
• Fussnoten: Gesehen am 19.07.2018
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 8(2018) Artikel-Nummer 3085, 10 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-018-21551-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577760492
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent model is obtained by a single intravenous or subcutaneous whole-parasite immunization. Whole-parasite immunization with radiation-attenuated sporozoites was equally protective as immunization with non-attenuated sporozoites under chemoprophylaxis. Both immunization regimens delayed the development of blood-stage parasites, but differences in cellular and humoral immune mechanisms were observed. Single-dose whole-parasite vaccination might serve as a relatively simple and feasible immunization approach to prevent life-threatening cerebral malaria.