Peripheral nerve diffusion tensor imaging (DTI)

• Verfasst von: Kronlage, Moritz [VerfasserIn]
• Verfasst von: Münch, Véronique [VerfasserIn]
• Verfasst von: Schwarz, Daniel [VerfasserIn]
• Verfasst von: Godel, Tim [VerfasserIn]
• Verfasst von: Uhlmann, Lorenz [VerfasserIn]
• Verfasst von: Heiland, Sabine [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Bäumer, Philipp [VerfasserIn]
• Titel: Peripheral nerve diffusion tensor imaging (DTI)
• Titelzusatz: normal values and demographic determinants in a cohort of 60 healthy individuals
• Verf.angabe: Moritz Kronlage, Véronique Schwehr, Daniel Schwarz, Tim Godel, Lorenz Uhlmann, Sabine Heiland, Martin Bendszus, Philipp Bäumer
• Jahr: 2018
• Umfang: 8 S.
• Fussnoten: First online: 11 December 2017 ; Gesehen am 19.07.2018
• Titel Quelle: Enthalten in: European radiology
• Ort Quelle: Berlin : Springer, 1991
• Jahr Quelle: 2018
• Band/Heft Quelle: 28(2018), 5, Seite 1801-1808
• ISSN Quelle: 1432-1084
• ISSN Quelle: 1613-3757
• DOI: doi:10.1007/s00330-017-5134-z
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577767632

Abstract

Objective: To identify demographic determinants of peripheral nerve diffusion tensor imaging (DTI) and to establish normal values for fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD). Methods: Sixty subjects were examined at 3 Tesla by single-shot DTI. FA, AD, RD, and MD were collected for the sciatic, tibial, median, ulnar, and radial nerve and were correlated with demographic variables. Results: Mean FA of all nerves declined with increasing age (r = −0.77), which could be explained by RD increasing (r = 0.56) and AD declining (r = −0.40) with age. Moreover, FA was inversely associated with height (r = −0.28), weight (r = −0.38) and BMI (r = −0.35). Although FA tended to be lower in men than women (p = 0.052), this difference became completely negligible after adjustment to body weight. A multiple linear regression model for FA was calculated with age and weight as predictors (defined by backward variable selection), yielding an R 2 = 0.71 and providing a correction formula to adjust FA for age and weight. Conclusion: Peripheral nerve DTI parameters depend on demographic variables. The most important determinants age and weight should be considered in all studies employing peripheral nerve DTI. Key points • Peripheral nerve diffusion tensor imaging (DTI) parameters depend on demographic variables. • Fractional anisotropy (FA) declines with increasing age and weight. • Gender does not systematically affect peripheral nerve DTI. • The formula presented here allows adjustment of FA for demographic variables.