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Verfasst von:Wegner, Frederic von [VerfasserIn]   i
 Wieder, Nicolas Wolfgang [VerfasserIn]   i
 Fink, Rainer [VerfasserIn]   i
Titel:Simulation strategies for calcium microdomains and calcium-regulated calcium channels
Verf.angabe:Frederic von Wegner, Nicolas Wieder, Rainer H.A. Fink
E-Jahr:2012
Jahr:14 February 2012
Umfang:15 S.
Fussnoten:Gesehen am 20.07.2018
Titel Quelle:Enthalten in: Calcium signaling
Ort Quelle:Dordrecht : Springer Netherlands, 2012
Jahr Quelle:2012
Band/Heft Quelle:(2012), Seite 553-567
ISBN Quelle:978-94-007-2888-2
Abstract:In this article, we present an overview of simulation strategies in the context of subcellular domains where calcium-dependent signaling plays an important role. The presentation follows the spatial and temporal scales involved and represented by each algorithm. As an exemplary cell type, we will mainly cite work done on striated muscle cells, i.e. skeletal and cardiac muscle. For these cells, a wealth of ultrastructural, biophysical and electrophysiological data is at hand. Moreover, these cells also express ubiquitous signaling pathways as they are found in many other cell types and thus, the generalization of the methods and results presented here is straightforward.The models considered comprise the basic calcium signaling machinery as found in most excitable cell types including Ca2+ ions, diffusible and stationary buffer systems, and calcium regulated calcium release channels. Simulation strategies can be differentiated in stochastic and deterministic algorithms. Historically, deterministic approaches based on the macroscopic reaction rate equations were the first models considered. As experimental methods elucidated highly localized Ca2+ signaling events occurring in femtoliter volumes, stochastic methods were increasingly considered. However, detailed simulations of single molecule trajectories are rarely performed as the computational cost implied is too large. On the mesoscopic level, Gillespie’s algorithm is extensively used in the systems biology community and with increasing frequency also in models of microdomain calcium signaling. To increase computational speed, fast approximations were derived from Gillespie’s exact algorithm, most notably the chemical Langevin equation and the τ-leap algorithm. Finally, in order to integrate deterministic and stochastic effects in multiscale simulations, hybrid algorithms are increasingly used. These include stochastic models of ion channels combined with deterministic descriptions of the calcium buffering and diffusion system on the one hand, and algorithms that switch between deterministic and stochastic simulation steps in a context-dependent manner on the other. The basic assumptions of the listed methods as well as implementation schemes are given in the text. We conclude with a perspective on possible future developments of the field.
DOI:doi:10.1007/978-94-007-2888-2_25
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1007/978-94-007-2888-2_25
 Volltext: https://link.springer.com/chapter/10.1007/978-94-007-2888-2_25
 DOI: https://doi.org/10.1007/978-94-007-2888-2_25
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-AusgabeWegner, Frederic von: Simulation strategies for calcium microdomains and calcium-regulated calcium channels. - 2012
K10plus-PPN:1577805631
Verknüpfungen:→ Sammelwerk

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