Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Lipniacki, Tomasz [VerfasserIn]  |
| Marciniak-Czochra, Anna [VerfasserIn]  |
Titel: | Transcriptional stochasticity in gene expression |
Verf.angabe: | Tomasz Lipniacki, Pawel Paszek, Anna Marciniak-Czochra, Allan R. Brasier, Marek Kimmel |
Jahr: | 2006 |
Jahr des Originals: | 2005 |
Umfang: | 20 S. |
Fussnoten: | Available online 21 July 2005 ; Gesehen am 20.07.2018 |
Titel Quelle: | Enthalten in: Journal of theoretical biology |
Ort Quelle: | Amsterdam : Elsevier Ltd., 1961 |
Jahr Quelle: | 2006 |
Band/Heft Quelle: | 238(2006), 2, Seite 348-367 |
ISSN Quelle: | 1095-8541 |
Abstract: | Due to the small number of copies of molecular species involved, such as DNA, mRNA and regulatory proteins, gene expression is a stochastic phenomenon. In eukaryotic cells, the stochastic effects primarily originate in regulation of gene activity. Transcription can be initiated by a single transcription factor binding to a specific regulatory site in the target gene. Stochasticity of transcription factor binding and dissociation is then amplified by transcription and translation, since target gene activation results in a burst of mRNA molecules, and each mRNA copy serves as a template for translating numerous protein molecules. In the present paper, we explore a mathematical approach to stochastic modeling. In this approach, the ordinary differential equations with a stochastic component for mRNA and protein levels in a single cells yield a system of first-order partial differential equations (PDEs) for two-dimensional probability density functions (pdf). We consider the following examples: Regulation of a single auto-repressing gene, and regulation of a system of two mutual repressors and of an activator-repressor system. The resulting PDEs are approximated by a system of many ordinary equations, which are then numerically solved. |
DOI: | doi:10.1016/j.jtbi.2005.05.032 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1016/j.jtbi.2005.05.032 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S002251930500250X |
| DOI: https://doi.org/10.1016/j.jtbi.2005.05.032 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Gene regulation |
| Probability density function |
| Stochasticity |
| Transcription |
| Transport-type equations |
K10plus-PPN: | 1577808916 |
Verknüpfungen: | → Zeitschrift |
Transcriptional stochasticity in gene expression / Lipniacki, Tomasz [VerfasserIn]; 2006 (Online-Ressource)
68287418