Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Lipniacki, Tomasz [VerfasserIn]   i
 Marciniak-Czochra, Anna [VerfasserIn]   i
Titel:Transcriptional stochasticity in gene expression
Verf.angabe:Tomasz Lipniacki, Pawel Paszek, Anna Marciniak-Czochra, Allan R. Brasier, Marek Kimmel
Jahr:2006
Jahr des Originals:2005
Umfang:20 S.
Fussnoten:Available online 21 July 2005 ; Gesehen am 20.07.2018
Titel Quelle:Enthalten in: Journal of theoretical biology
Ort Quelle:Amsterdam : Elsevier Ltd., 1961
Jahr Quelle:2006
Band/Heft Quelle:238(2006), 2, Seite 348-367
ISSN Quelle:1095-8541
Abstract:Due to the small number of copies of molecular species involved, such as DNA, mRNA and regulatory proteins, gene expression is a stochastic phenomenon. In eukaryotic cells, the stochastic effects primarily originate in regulation of gene activity. Transcription can be initiated by a single transcription factor binding to a specific regulatory site in the target gene. Stochasticity of transcription factor binding and dissociation is then amplified by transcription and translation, since target gene activation results in a burst of mRNA molecules, and each mRNA copy serves as a template for translating numerous protein molecules. In the present paper, we explore a mathematical approach to stochastic modeling. In this approach, the ordinary differential equations with a stochastic component for mRNA and protein levels in a single cells yield a system of first-order partial differential equations (PDEs) for two-dimensional probability density functions (pdf). We consider the following examples: Regulation of a single auto-repressing gene, and regulation of a system of two mutual repressors and of an activator-repressor system. The resulting PDEs are approximated by a system of many ordinary equations, which are then numerically solved.
DOI:doi:10.1016/j.jtbi.2005.05.032
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1016/j.jtbi.2005.05.032
 Volltext: http://www.sciencedirect.com/science/article/pii/S002251930500250X
 DOI: https://doi.org/10.1016/j.jtbi.2005.05.032
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Gene regulation
 Probability density function
 Stochasticity
 Transcription
 Transport-type equations
K10plus-PPN:1577808916
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68287418   QR-Code
zum Seitenanfang