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Verfasst von:Kahle, Nadine [VerfasserIn]   i
 Hänsch, Gertrud Maria [VerfasserIn]   i
Titel:Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1)
Verf.angabe:N.A. Kahle, G. Brenner-Weiss, J. Overhage, U. Obst, G.M. Hänsch
Jahr:2013
Jahr des Originals:2012
Umfang:7 S.
Fussnoten:Gesehen am 22.07.2018 ; Available online: 14 February 2012
Titel Quelle:Enthalten in: Immunobiology
Ort Quelle:München : Elsevier, 1979
Jahr Quelle:2013
Band/Heft Quelle:218(2013), 2, Seite 145-151
ISSN Quelle:1878-3279
Abstract:When bacteria colonize surfaces, they socialize and form biofilms. This process is well regulated and relies on the communication among the bacteria via so-called “quorum sensing molecules”. Among those, N-(3-oxododecanoyl)-l-homoserine lactone (AHL-12), generated by Pseudomonas aeruginosa and other Gram-negative bacteria, activates not only bacteria but also interacts with mammalian cells. Among others, it activates phagocytic cells and - as we had shown previously - it is chemotactic for human polymorphonuclear neutrophils (PMN) in vitro. In the present study, we analyzed the signalling pathway of AHL-12 in PMN. We focused on the mitogen activated protein (MAP) kinase p38, because SB203580, an inhibitor of p38, prevented the AHL-12 induced chemotaxis. We found that in response to AHL-12, p38 was phosphorylated within minutes, as was its downstream target, the MAPKAP-Kinase-2 (MK2). In PMN, the major substrate of MK2 is the leukocyte specific protein 1 (LSP1), which binds to F-actin and participates directly in actin polymerization and cell migration. In response to AHL-12, LSP1 was phosphorylated and co-localized with F-actin in polarized PMN, suggesting that AHL-12-induced migration depended on p38 and LSP1 activation.
DOI:doi:10.1016/j.imbio.2012.02.004
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag ; Resolving-System: http://www.sciencedirect.com/science/article/pii/S017129851200040X
 Volltext: http://dx.doi.org/10.1016/j.imbio.2012.02.004
 DOI: https://doi.org/10.1016/j.imbio.2012.02.004
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Acyl homoserine lactones (AHLs)
 Chemotaxis
 Human neutrophils
 LSP1
 p38 Map Kinase
 Quorum sensing molecules
K10plus-PPN:1577816757
Verknüpfungen:→ Zeitschrift

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