Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Kahle, Nadine [VerfasserIn]  |
| Hänsch, Gertrud Maria [VerfasserIn]  |
Titel: | Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1) |
Verf.angabe: | N.A. Kahle, G. Brenner-Weiss, J. Overhage, U. Obst, G.M. Hänsch |
Jahr: | 2013 |
Jahr des Originals: | 2012 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 22.07.2018 ; Available online: 14 February 2012 |
Titel Quelle: | Enthalten in: Immunobiology |
Ort Quelle: | München : Elsevier, 1979 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 218(2013), 2, Seite 145-151 |
ISSN Quelle: | 1878-3279 |
Abstract: | When bacteria colonize surfaces, they socialize and form biofilms. This process is well regulated and relies on the communication among the bacteria via so-called “quorum sensing molecules”. Among those, N-(3-oxododecanoyl)-l-homoserine lactone (AHL-12), generated by Pseudomonas aeruginosa and other Gram-negative bacteria, activates not only bacteria but also interacts with mammalian cells. Among others, it activates phagocytic cells and - as we had shown previously - it is chemotactic for human polymorphonuclear neutrophils (PMN) in vitro. In the present study, we analyzed the signalling pathway of AHL-12 in PMN. We focused on the mitogen activated protein (MAP) kinase p38, because SB203580, an inhibitor of p38, prevented the AHL-12 induced chemotaxis. We found that in response to AHL-12, p38 was phosphorylated within minutes, as was its downstream target, the MAPKAP-Kinase-2 (MK2). In PMN, the major substrate of MK2 is the leukocyte specific protein 1 (LSP1), which binds to F-actin and participates directly in actin polymerization and cell migration. In response to AHL-12, LSP1 was phosphorylated and co-localized with F-actin in polarized PMN, suggesting that AHL-12-induced migration depended on p38 and LSP1 activation. |
DOI: | doi:10.1016/j.imbio.2012.02.004 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: http://www.sciencedirect.com/science/article/pii/S017129851200040X |
| Volltext: http://dx.doi.org/10.1016/j.imbio.2012.02.004 |
| DOI: https://doi.org/10.1016/j.imbio.2012.02.004 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Acyl homoserine lactones (AHLs) |
| Chemotaxis |
| Human neutrophils |
| LSP1 |
| p38 Map Kinase |
| Quorum sensing molecules |
K10plus-PPN: | 1577816757 |
Verknüpfungen: | → Zeitschrift |
Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1) / Kahle, Nadine [VerfasserIn]; 2013 (Online-Ressource)
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