Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

• Verfasst von: Brings, Sebastian [VerfasserIn]
• Verfasst von: Fleming, Thomas [VerfasserIn]
• Verfasst von: Freichel, Marc [VerfasserIn]
• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Titel: Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention
• Verf.angabe: Sebastian Brings, Thomas Fleming, Marc Freichel, Martina U. Muckenthaler, Stephan Herzig and Peter P. Nawroth
• Fussnoten: Gesehen am 23.07.2018
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Jahr Quelle: 2017
• Band/Heft Quelle: 18(2017,5) Artikel-Nummer 984, 24 Seiten
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms18050984
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577829530

Abstract

Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is enhanced in diabetes and is associated with the development of diabetic complications. In the current review, we discuss mechanisms that lead to enhanced AGE levels in the context of diabetes and diabetic complications. The methylglyoxal-detoxifying glyoxalase system as well as alternative pathways of AGE detoxification are summarized. Therapeutic approaches to interfere with different pathways of AGE formation are presented.