Notch signaling facilitates crossing of endothelial barriers by tumor cells

• Verfasst von: Rodriguez-Vita, Juan [VerfasserIn]
• Verfasst von: Fischer, Andreas [VerfasserIn]
• Titel: Notch signaling facilitates crossing of endothelial barriers by tumor cells
• Verf.angabe: Juan Rodriguez-Vita & Andreas Fischer
• E-Jahr: 2017
• Jahr: 03 April 2017
• Umfang: 3 S.
• Fussnoten: Gesehen am 23.07.2018
• Titel Quelle: Enthalten in: Molecular & cellular oncology
• Ort Quelle: London : Taylor & Francis, 2014
• Jahr Quelle: 2017
• Band/Heft Quelle: 4(2017), 3, Artikel-ID e1311828, Seite 1-3
• ISSN Quelle: 2372-3556
• DOI: doi:10.1080/23723556.2017.1311828
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Angiogenesis
• Sach-SW: endothelial cell senescence
• Sach-SW: metastasis
• Sach-SW: neutrophils
• Sach-SW: notch signaling
• K10plus-PPN: 1577856864

Abstract

Blood vessels supply tumor cells with oxygen and nutrients and provide the basis for metastatic dissemination. In addition, endothelial cells can provide factors that orchestrate the behavior of tumor cells. Here, we expand upon our previous findings that link activation of Notch signaling in the endothelium to cellular senescence, weakening of cell junctions, and expression of adhesion molecules, which facilitates tumor and immune cell migration across the vessel wall and homing at distant sites.