Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Frank, Roland [VerfasserIn]  |
| Gabel, Michael [VerfasserIn]  |
| Heiß, Kirsten [VerfasserIn]  |
| Müller, Ann-Kristin [VerfasserIn]  |
| Graw, Frederik [VerfasserIn]  |
Titel: | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics |
Verf.angabe: | Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw |
Fussnoten: | Das Pluszeichen ist im Titel hochgestellt ; Gesehen am 24.07.2018 |
Titel Quelle: | Enthalten in: Frontiers in immunology |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 9(2018) Artikel-Nummer 1137, 13 Seiten |
ISSN Quelle: | 1664-3224 |
Abstract: | Whole sporozoite vaccines (WSV) represent one of the most promising strategies to induce protection against malaria. However, the development of efficient vaccination protocols still remains a major challenge. To understand how the generation of immunity is affected by variations in vaccination dosage and frequency, we systematically analyzed intrasplenic and intrahepatic CD8+ T cell responses following varied immunizations of mice with radiation-attenuated sporozoites (RAS). By combining experimental data and mathematical modeling, our analysis indicates a reversing role of spleen and liver in the generation of protective liver-resident CD8+ T cells during priming and booster injections: While the spleen acts as a critical source compartment during priming, the increase in vaccine-induced hepatic T cell levels is likely due to local reactivation in the liver in response to subsequent booster injections. Higher dosing accelerates the efficient generation of liver-resident CD8+ T cells by especially affecting their local reactivation. In addition, we determine the differentiation and migration pathway from splenic precursors towards hepatic memory cells thereby presenting a mechanistic framework for the impact of various vaccination protocols on these dynamics. Thus, our work provides important insights into organ-specific CD8+ T cell dynamics and their role and interplay in the formation of protective immunity against malaria. |
DOI: | doi:10.3389/fimmu.2018.01137 |
URL: | Kostenfrei: Verlag: http://dx.doi.org/10.3389/fimmu.2018.01137 |
| Kostenfrei: Verlag: https://www.frontiersin.org/articles/10.3389/fimmu.2018.01137/full |
| DOI: https://doi.org/10.3389/fimmu.2018.01137 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1577887999 |
Verknüpfungen: | → Zeitschrift |
|
|
| |
Lokale URL UB: | Zum Volltext |
Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics / Frank, Roland [VerfasserIn] (Online-Ressource)
68288154