Saturation-recovery myocardial T 1 -mapping during systole

• Verfasst von: Meßner, Nadja [VerfasserIn]
• Verfasst von: Budjan, Johannes [VerfasserIn]
• Verfasst von: Loßnitzer, Dirk [VerfasserIn]
• Verfasst von: Papavassiliu, Theano [VerfasserIn]
• Verfasst von: Schad, Lothar R. [VerfasserIn]
• Verfasst von: Weingärtner, Sebastian [VerfasserIn]
• Verfasst von: Zöllner, Frank G. [VerfasserIn]
• Titel: Saturation-recovery myocardial T 1 -mapping during systole
• Titelzusatz: accurate and robust quantification in the presence of arrhythmia
• Verf.angabe: Nadja M. Meßner, Johannes Budjan, Dirk Loßnitzer, Theano Papavassiliu, Lothar R. Schad, Sebastian Weingärtner & Frank G. Zöllner
• E-Jahr: 2018
• Jahr: 27 March 2018
• Umfang: 9 S.
• Fussnoten: Gesehen am 24.07.2018 ; Die 1 ist im Titel tiefgestellt
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 8(2018) Artikel-Nummer 5251, 9 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-018-23506-z
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577894081
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Myocardial T1-mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate variability, we introduce a systolic saturation-recovery T1-mapping method. The Saturation-Pulse Prepared Heart-rate independent Inversion-Recovery (SAPPHIRE) T1-mapping method was modified to enable imaging during systole. Phantom measurements were used to evaluate the insensitivity of systolic T1-mapping towards heart-rate variability. In-vivo feasibility and accuracy were demonstrated in ten healthy volunteers with native and post-contrast T1-mappping during systole and diastole. To show benefits in the presence of RR-variability, six arrhythmic patients underwent native T1-mapping. Resulting systolic SAPPHIRE T1-values showed no dependence on arrhythmia in phantom (CoV < 1%). In-vivo, significantly lower T1 (1563 ± 56 ms, precision: 84.8 ms) and ECV-values (0.20 ± 0.03) than during diastole (T1 = 1580 ± 62 ms, p = 0.0124; precision: 60.2 ms, p = 0.03; ECV = 0.21 ± 0.03, p = 0.0098) were measured, with a strong correlation of systolic and diastolic T1 (r = 0.89). In patients, mis-triggering-induced motion caused significant imaging artifacts in diastolic T1-maps, whereas systolic T1-maps displayed resilience to arrythmia. In conclusion, the proposed method enables saturation-recovery T1-mapping during systole, providing increased robustness against partial-voluming compared to diastolic imaging, for the benefit of T1-measurements in arrhythmic patients.