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Verfasst von:Müller-Christmann, Christine [VerfasserIn]   i
 Uhlmann, Lorenz [VerfasserIn]   i
 Klose, Christina [VerfasserIn]   i
 Hänßle, Holger [VerfasserIn]   i
Titel:Automated, computer-guided PASI measurements by digital image analysis versus conventional physicians’ PASI calculations
Titelzusatz:study protocol for a comparative, single-centre, observational study
Verf.angabe:Christine Fink, Lorenz Uhlmann, Christina Klose, Holger A. Haenssle
E-Jahr:2018
Jahr:May 17, 2018
Umfang:4 S.
Fussnoten:Gesehen am 24.07.2018
Titel Quelle:Enthalten in: BMJ open
Ort Quelle:London : BMJ Publishing Group, 2011
Jahr Quelle:2018
Band/Heft Quelle:8(2018,5) Artikel-Nummer e018461, 4 Seiten
ISSN Quelle:2044-6055
Abstract:Introduction: Reliable and accurate assessment of severity in psoriasis is very important in order to meet indication criteria for initiation of systemic treatment or to evaluate treatment efficacy. The most acknowledged tool for measuring the extent of psoriatic skin changes is the Psoriasis Area and Severity Index (PASI). However, the calculation of PASI can be tedious and subjective and high intraobserver and interobserver variability is an important concern. Therefore, there is a great need for a standardised and objective method that guarantees a reproducible PASI calculation. Within this study we will investigate the precision and reproducibility of automated, computer-guided PASI measurements in comparison to trained physicians to address these limitations. Methods and analysis: Non-interventional analyses of PASI calculations by either physicians in a prospective versus retrospective setting or an automated computer-guided algorithm in 120 patients with plaque psoriasis. All retrospective PASI calculations by physicians or by the computer algorithm are based on total body digital images. The primary objective of this study is comparison of automated computer-guided PASI measurements by means of digital image analysis versus conventional, prospective or retrospective physicians' PASI assessments. Secondary endpoints include (1) the assessment of physicians’ interobserver variance in PASI calculations, (2) the assessment of physicians’ intraobserver variance in PASI assessments of the same patients' images after a time interval of at least 4 weeks, (3) the assessment of the deviation between physicians’ prospective versus retrospective PASI calculations, and (4) the reproducibility of automated computer-guided PASI measurements by assessment of two sets of total body digital images of the same patients taken at one time point. Ethics: Ethical approval was provided by the Ethics Committee of the Medical Faculty of the University of Heidelberg (ethics approval number S-379/2016). Trial registration number DRKS00011818; Results.
DOI:doi:10.1136/bmjopen-2017-018461
URL:kostenfrei: Volltext: http://dx.doi.org/10.1136/bmjopen-2017-018461
 kostenfrei: Volltext: https://bmjopen.bmj.com/content/8/5/e018461
 DOI: https://doi.org/10.1136/bmjopen-2017-018461
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:PASI
 plaque psoriasis
 psoriasis
K10plus-PPN:157790088X
Verknüpfungen:→ Zeitschrift
 
 
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