The biocompatibility of metal-organic framework coatings

• Verfasst von: Hanke, Maximilian [VerfasserIn]
• Verfasst von: Bauer, Stella [VerfasserIn]
• Verfasst von: Christophis, Christof [VerfasserIn]
• Verfasst von: Rosenhahn, Axel [VerfasserIn]
• Titel: The biocompatibility of metal-organic framework coatings
• Titelzusatz: an investigation on the stability of SURMOFs with regard to water and selected cell culture media
• Verf.angabe: Maximilian Hanke, Hasan K. Arslan, Stella Bauer, Olexandra Zybaylo, Christof Christophis, Hartmut Gliemann, Axel Rosenhahn, and Christof Wöll
• E-Jahr: 2012
• Jahr: 16 April 2012
• Umfang: 8 S.
• Fussnoten: Gesehen am 24.07.2018 ; Published online 16 April 2012
• Titel Quelle: Enthalten in: Langmuir
• Ort Quelle: Washington, DC : ACS Publ., 1985
• Jahr Quelle: 2012
• Band/Heft Quelle: 28(2012), 17, Seite 6877-6884
• ISSN Quelle: 1520-5827
• DOI: doi:10.1021/la300457z
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 157790379X

Abstract

Highly porous thin films based on a [Cu(bdc)2]n (bdc = benzene-1,4-dicarboxylic acid) metal−organic framework, MOF, grown using liquid-phase epitaxy (LPE) show remarkable stability in pure water as well as in artificial seawater. This opens the possibility to use these highly porous coatings for environmental and life science applications. Here we characterize in detail the stability of these SURMOF 2 thin films under aqueous and cell culture conditions. We find that the material degrades only very slowly in water and artificial seawater (ASW) whereas in typical cell culture media (PBS and DMEM) a rapid dissolution is observed. The release of Cu2+ ions resulting from the dissolution of the SURMOF 2 in the liquids exhibits no adverse effect on the adhesion of fibroblasts, prototype eukaryotic cells, to the substrate and their subsequent proliferation, thus demonstrating the biocompatibility of SURMOF 2 surface coatings. Thus, the results are an important step toward application of these porous materials as a slow release matrix, for example, for pharmaceuticals and growth factors.