Transient P2X7 receptor activation triggers macrophage death independent of toll-like receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins

• Verfasst von: Hanley, Peter J. [VerfasserIn]
• Verfasst von: Filippov, Mikhail A. [VerfasserIn]
• Titel: Transient P2X7 receptor activation triggers macrophage death independent of toll-like receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins
• Verf.angabe: Peter J. Hanley, Moritz Kronlage, Carsten Kirschning, Adriana del Rey, Francesco Di Virgilio, Jens Leipziger, Iain P. Chessell, Sarah Sargin, Mikhail A. Filippov, Otto Lindemann, Simon Mohr, Volker Königs, Hermann Schillers, Martin Bähler, and Albrecht Schwab
• Umfang: 15 S.
• Fussnoten: Im Titel ist "7" tiefgestellt. - Gesehen am 24.07.2018
• Titel Quelle: Enthalten in: The journal of biological chemistry
• Jahr Quelle: 2012
• Band/Heft Quelle: 287(2012), 13, S. 10650-10663
• ISSN Quelle: 1083-351X
• DOI: doi:10.1074/jbc.M111.332676
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1577905172

Abstract

Background: P2X7 receptors are thought to be primarily involved in inflammatory signaling. Results: Transient (1- 4 min) high ATP induced delayed (hours) cell death in macrophages from WT and TLR2/4, Casp1, or Panx1 knock-out mice. Conclusion: Transient P2X7 receptor activation triggers macrophage-selective apoptotic cell death independent of TLR signaling, Casp1, and Panx1. Significance: P2X7 receptors function foremost as death triggers in macrophages.