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Verfasst von:Triphan, Simon M. F. [VerfasserIn]   i
 Biederer, Jürgen [VerfasserIn]   i
 Burmester, Kerstin [VerfasserIn]   i
 Fellhauer, Iven [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Heußel, Claus Peter [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
 Jobst, Bertram [VerfasserIn]   i
Titel:Design and application of an MR reference phantom for multicentre lung imaging trials
Verf.angabe:Simon M.F. Triphan, Jürgen Biederer, Kerstin Burmester, Iven Fellhauer, Claus F. Vogelmeier, Rudolf A. Jörres, Hans-Ulrich Kauczor, Claus P. Heußel, Mark O. Wielpütz, Bertram J. Jobst
E-Jahr:2018
Jahr:July 5, 2018
Umfang:19 S.
Fussnoten:Gesehen am 25.07.2018
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2018
Band/Heft Quelle:13(2018,7) Artikel-Nummer e0199148, 19 Seiten
ISSN Quelle:1932-6203
Abstract:Introduction As there is an increasing number of multicentre lung imaging studies with MRI in patients, dedicated reference phantoms are required to allow for the assessment and comparison of image quality in multi-vendor and multi-centre environments. However, appropriate phantoms for this purpose are so far not available commercially. It was therefore the purpose of this project to design and apply a cost-effective and simple to use reference phantom which addresses the specific requirements for imaging the lungs with MRI. Methods The phantom was designed to simulate 4 compartments (lung, blood, muscle and fat) which reflect the specific conditions in proton-MRI of the chest. Multiple phantom instances were produced and measured at 15 sites using a contemporary proton-MRI protocol designed for an in vivo COPD study at intervals over the course of the study. Measures of signal- and contrast-to-noise ratio, as well as structure and edge depiction were extracted from conventionally acquired images using software written for this purpose. Results For the signal to noise ratio, low intra-scanner variability was found with 4.5% in the lung compartment, 4.0% for blood, 3.3% for muscle and 3.7% for fat. The inter-scanner variability was substantially higher, with 41%, 32%, 27% and 32% for the same order of compartments. In addition, measures of structure and edge depiction were found to both vary significantly among several scanner types and among scanners of the same model which were equipped with different gradient systems. Conclusion The described reference phantom reproducibly quantified image quality aspects and detected substantial inter-scanner variability in a typical pulmonary multicentre proton MRI study, while variability was greater in lung tissue compared to other tissue types. Accordingly, appropriate reference phantoms can help to detect bias in multicentre in vivo study results and could also be used to harmonize equipment or data.
DOI:doi:10.1371/journal.pone.0199148
URL:Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1371/journal.pone.0199148
 Kostenfrei: Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199148
 DOI: https://doi.org/10.1371/journal.pone.0199148
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biomarkers
 Blood
 Computed axial tomography
 Fats
 In vivo imaging
 Magnetic resonance imaging
 Protons
 Pulmonary imaging
K10plus-PPN:1577918983
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