| Online-Ressource |
Verfasst von: | Gleißner, Christian A. [VerfasserIn]  |
| Erbel, Christian [VerfasserIn]  |
| Linden, Fabian [VerfasserIn]  |
| Domschke, Gabriele [VerfasserIn]  |
| Akhavanpoor, Mohammadreza [VerfasserIn]  |
| Helmes, Christian Michael [VerfasserIn]  |
| Dösch, Andreas [VerfasserIn]  |
| Kleber, Marcus E. [VerfasserIn]  |
| Katus, Hugo [VerfasserIn]  |
| März, Winfried [VerfasserIn]  |
Titel: | Galectin-3 binding protein, coronary artery disease and cardiovascular mortality |
Titelzusatz: | insights from the LURIC study |
Verf.angabe: | Christian A. Gleissner, Christian Erbel, Fabian Linden, Gabriele Domschke, Mohammadreza Akhavanpoor, Christian M. Helmes, Andreas O. Doesch, Marcus E. Kleber, Hugo A. Katus, Winfried Maerz |
E-Jahr: | 2017 |
Jahr: | 23 March 2017 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 01.08.2018 |
Titel Quelle: | Enthalten in: Atherosclerosis |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1970 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 260(2017), Seite 121-129 |
ISSN Quelle: | 1879-1484 |
Abstract: | Background and aims Galectin-3 binding protein (Gal-3BP) has been associated with inflammation and cancer, however, its role in coronary artery disease (CAD) and cardiovascular outcome remains unclear. Methods Gal-3BP plasma levels were measured by ELISA in 2922 individuals from the LURIC study (62.7 ± 10.6 years, 62.7% male). All-cause and cardiovascular mortality was assessed by Kaplan-Meier analysis and Cox proportional hazards regression. Causal involvement of Gal-3BP was tested for by Mendelian randomization. Gal-3BP effects on human monocyte-derived macrophages were assessed in vitro. Results During 8.8 ± 3.0 years, 866 individuals died, 654 of cardiovascular causes. There was a significant increase in all-cause and cardiovascular mortality with increasing Gal-3BP quintiles. After thorough adjustment, all-cause mortality remained significantly increased in the fifth Gal-3BP quintile (HRQ5 1.292 (1.030-1.620), p = 0.027); cardiovascular mortality remained increased in Gal-3BP quintiles two to five (HRQ51.433 (1.061-1.935, p = 0.019). Gal-3BP levels were not associated with diagnosis and extent of coronary artery disease. In addition, Mendelian randomization did not show a direct causal relationship between Gal-3BP levels and mortality. Gal-3BP levels were, however, independently associated with markers of metabolic and inflammatory distress. In vitro, Gal-3BP induced a pro-inflammatory response in human monocyte-derived macrophages. Adding Gal-3BP levels to the ESC score improved risk assessment in patients with ESC SCORE-based risk >5% (p = 0.010). Conclusions In a large clinical cohort of CAD patients, Gal-3BP levels are independently associated with all-cause and cardiovascular mortality. The underlying mechanisms may likely involve metabolic and inflammatory distress. To further evaluate the potential clinical value of Gal-3BP, prospective studies are needed. |
DOI: | doi:10.1016/j.atherosclerosis.2017.03.031 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.atherosclerosis.2017.03.031 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0021915017301338 |
| DOI: https://doi.org/10.1016/j.atherosclerosis.2017.03.031 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Atherosclerosis |
| Biomarker |
| Coronary artery disease |
| Inflammation |
K10plus-PPN: | 1577926838 |
Verknüpfungen: | → Zeitschrift |
Galectin-3 binding protein, coronary artery disease and cardiovascular mortality / Gleißner, Christian A. [VerfasserIn]; 23 March 2017 (Online-Ressource)