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Verfasst von:Marciniak-Czochra, Anna [VerfasserIn]   i
 Kimmel, Marek [VerfasserIn]   i
Titel:Modelling of early lung cancer progression
Titelzusatz:influence of growth factor production and cooperation between partially transformed cells
Verf.angabe:Anna Marciniak-Czochra and Marek Kimmel
Jahr:2007
Umfang:27 S.
Fussnoten:Gesehen am 25.07.2018
Titel Quelle:Enthalten in: Mathematical models and methods in applied sciences (M 3 AS)
Ort Quelle:Singapore [u.a.] : World Scientific, 1991
Jahr Quelle:2007
Band/Heft Quelle:17(2007), supp01, Seite 1693-1719
ISSN Quelle:1793-6314
Abstract:The generally accepted Moolgavkar's theory of carcinogenesis assumes that all cancers are clonal, i.e. that they arise from progressive genetic deregulation in a cell pedigree originating from a single ancestral cell.18 However, recently the clonal theory has been challenged by the field theory of carcinogenesis, which admits the possibility of simultaneous changes in tissue subject to carcinogenic agents, such as tobacco smoke in lung cancer. Axelrod et al.1 formulated a more detailed framework, in which partially transformed cells depend in a mutualistic way on growth factors they produce, in this way enabling these cells to proliferate and undergo further transformations. On the other hand, the field theory assumes spatial distribution of precancerous cells and indeed there exists evidence that early-stage precancerous lesions in lung cancer progress along linear, tubular, or irregular surface structures. This seems to be the case for the atypical adenomatous hyperplasia (AAH),10 a likely precursor of adenocarcinoma of the lung. In this paper we explore the consequences of linking the model of spatial growth of precancerous cells,12 with the mutualistic hypothesis. We investigate the solutions of the model using analytical and computational techniques. The picture emerging from our modelling indicates that production of growth factors by cells considered may lead to diffusion-driven instability, which in turn may lead either to decay of both population, or to emergence of local growth foci, represented by spike-like solutions. Mutualism may, in some situations, increase the stability of solutions. One important conclusion is that models of field carcinogenesis, which include spatial effects, generally have very different behaviour compared to ODE models.
DOI:doi:10.1142/S0218202507002443
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1142/S0218202507002443
 DOI: https://doi.org/10.1142/S0218202507002443
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1577931637
Verknüpfungen:→ Zeitschrift

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