Status: Bibliographieeintrag
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| Online-Ressource |
Verfasst von: | Donadieu, Maxime [VerfasserIn]  |
| Schad, Lothar R. [VerfasserIn]  |
Titel: | Metabolic counterparts of sodium accumulation in multiple sclerosis |
Titelzusatz: | a whole brain 23Na-MRI and fast 1H-MRSI study |
Verf.angabe: | Maxime Donadieu, Yann Le Fur, Adil Maarouf, Soraya Gherib, Ben Ridley, Lauriane Pini, Stanislas Rapacchi, Sylviane Confort-Gouny, Maxime Guye, Lothar R Schad, Andrew A Maudsley, Jean Pelletier, Bertrand Audoin, Wafaa Zaaraoui and Jean-Philippe Ranjeva |
Jahr: | 2019 |
Jahr des Originals: | 2017 |
Umfang: | 19 S. |
Fussnoten: | First Published October 24, 2017 ; Gesehen am 19.06.2019 ; Im Titelzusatz ist "23" und "1" hochgestellt |
Titel Quelle: | Enthalten in: Multiple sclerosis journal |
Ort Quelle: | London : Sage, 1995 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 25(2019), 1, Seite 39-47 |
ISSN Quelle: | 1477-0970 |
Abstract: | Background: Increase of brain total sodium concentrations (TSC) is present in multiple sclerosis (MS), but its pathological involvement has not been assessed yet. Objective: To determine in vivo the metabolic counterpart of brain sodium accumulation. Materials/methods: Whole brain 23Na-MR imaging and 3D-1H-EPSI data were collected in 21 relapsing-remitting multiple sclerosis (RRMS) patients and 20 volunteers. Metabolites and sodium levels were extracted from several regions of grey matter (GM), normal-appearing white matter (NAWM) and white matter (WM) T2 lesions. Metabolic and ionic levels expressed as Z-scores have been averaged over the different compartments and used to explain sodium accumulations through stepwise regression models. Results: MS patients showed significant 23Na accumulations with lower choline and glutamate-glutamine (Glx) levels in GM; 23Na accumulations with lower N-acetyl aspartate (NAA), Glx levels and higher Myo-Inositol (m-Ins) in NAWM; and higher 23Na, m-Ins levels with lower NAA in WM T2 lesions. Regression models showed associations of TSC increase with reduced NAA in GM, NAWM and T2 lesions, as well as higher total-creatine, and smaller decrease of m-Ins in T2 lesions. GM Glx levels were associated with clinical scores. Conclusion: Increase of TSC in RRMS is mainly related to neuronal mitochondrial dysfunction while dysfunction of neuro-glial interactions within GM is linked to clinical scores. |
DOI: | doi:10.1177/1352458517736146 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1177/1352458517736146 |
| Volltext: http://journals.sagepub.com/doi/10.1177/1352458517736146 |
| DOI: https://doi.org/10.1177/1352458517736146 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1577948831 |
Verknüpfungen: | → Zeitschrift |
Metabolic counterparts of sodium accumulation in multiple sclerosis / Donadieu, Maxime [VerfasserIn]; 2019 (Online-Ressource)
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