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| Verfasst von: | Rehnitz, Julia [VerfasserIn]  |
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| | Alcoba, Diego Duarte [VerfasserIn] |
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| | Dietrich, Jens Erik [VerfasserIn] |
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| | Youness, Berthe [VerfasserIn] |
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| | Hinderhofer, Katrin [VerfasserIn] |
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| | Messmer, Birgitta [VerfasserIn] |
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| | Freis, Alexander [VerfasserIn] |
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| | Strowitzki, Thomas [VerfasserIn] |
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| | Germeyer, Ariane [VerfasserIn] |
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| Titel: | FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve |
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| Verf.angabe: | Julia Rehnitz, Diego D. Alcoba, Ilma S. Brum, Jens E. Dietrich, Berthe Youness, Katrin Hinderhofer, Birgitta Messmer, Alexander Freis, Thomas Strowitzki and Ariane Germeyer |
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| E-Jahr: | 2018 |
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| Jahr: | 7 July 2018 |
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| Fussnoten: | Gesehen am 26.07.2018 |
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| Titel Quelle: | Enthalten in: Reproductive biology and endocrinology |
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| Ort Quelle: | London : Biomed Central, 2003 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 16(2018) Artikel-Nummer 65, 9 Seiten |
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| ISSN Quelle: | 1477-7827 |
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| Abstract: | Fragile-X-Mental-Retardation-1- (FMR1)-gene is supposed to be a key gene for ovarian reserve and folliculogenesis. It contains in its 5’-UTR a triplet-base-repeat (CGG), that varies between 26 and 34 in general population. CGG-repeat-lengths with 55-200 repeats (pre-mutation = PM) show instable heredity with a tendency to increase and are associated with premature-ovarian-insufficiency or failure (POI/POF) in about 20%. FMR1-mRNA-expression in leucocytes and granulosa cells (GCs) increases with CGG-repeat-length in PM-carriers, but variable FMR1-expression profiles were also described in women with POI without PM-FMR1 repeat-length. Additionally, associations between low numbers of retrieved oocytes and elevated FMR1-expression levels have been shown in GCs of females with mid-range PM-CGG-repeats without POI. Effects of FMR1-repeat-lengths-deviations (n < 26 or n > 34) below the PM range (n < 55) on ovarian reserve and response to ovarian stimulation remain controversial. |
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| DOI: | doi:10.1186/s12958-018-0383-5 |
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| URL: | kostenfrei: Volltext: http://dx.doi.org/10.1186/s12958-018-0383-5 |
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| | kostenfrei: Volltext: https://doi.org/10.1186/s12958-018-0383-5 |
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| | DOI: https://doi.org/10.1186/s12958-018-0383-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Reproduktion: | Elektronische Reproduktion: Rehnitz, Julia, 1980 -: FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve. - London: BioMed Central, 2018. - 1 Online-Ressource (9 Seiten) |
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| K10plus-PPN: | 1577959167 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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FMR1 expression in human granulosa cells increases with exon 1 CGG repeat length depending on ovarian reserve / Rehnitz, Julia [VerfasserIn]; 7 July 2018 (Online-Ressource)
