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Verfasst von:Hagens, Cornelia von [VerfasserIn]   i
 Schiller, Petra [VerfasserIn]   i
 Godbillon, Bettina [VerfasserIn]   i
 Osburg, Julia [VerfasserIn]   i
 Klose, Christina [VerfasserIn]   i
 Limprecht, Ronald [VerfasserIn]   i
 Strowitzki, Thomas [VerfasserIn]   i
Titel:Treating menopausal symptoms with a complex remedy or placebo
Titelzusatz:a randomized controlled trial
Verf.angabe:C. von Hagens, P. Schiller, B. Godbillon, J. Osburg, C. Klose, R. Limprecht, T. Strowitzki
Jahr:2012
Umfang:10 S.
Fussnoten:Published online: 23 Oct 2011 ; Gesehen am 26.07.2018
Titel Quelle:Enthalten in: Climacteric
Ort Quelle:London [u.a.] : Informa Healthcare, 1998
Jahr Quelle:2012
Band/Heft Quelle:15(2012), 4, Seite 358-367
ISSN Quelle:1473-0804
Abstract:Objective To evaluate the efficacy and safety of a complex remedy compared with placebo to treat menopausal symptoms.Methods A total of 102 peri- and postmenopausal women requiring treatment for menopausal symptoms were randomized to receive a complex anthroposophic remedy prepared in the homeopathic manner (Apis regina tota GL D4, Argentum metallicum D5, Ovaria bovis GL D4), 3 × 10 globuli daily (2 × 12 weeks) and placebo (12 weeks) in different orders of remedy (R) and placebo (P) (1: R/R/P, 2: P/R/R, 3: R/P/R). The primary endpoint was change in climacteric symptoms assessed by the Menopause Rating Scale II (MRS II) after 12 weeks. Secondary endpoints were changes of symptoms and safety throughout the study.Results Reduction of symptoms after 12 weeks did not differ between remedy and placebo (total score MRS II: -1.4, 95% confidence interval (CI) −2.8 to 0 vs. −2.3, 95% CI −4.4 to −0.3, p = 0.441) and had no clinical relevance (defined as reduction in MRS II ≥ −3.5). Comparison of secondary outcomes at 12 weeks between remedy and placebo or between groups after the 2nd or 3rd period compared to previous periods did not differ. Treatment with remedy for 24 consecutive weeks did not reach clinical relevance either. However, total reduction of symptoms after three periods in Group 1 (R/R/P) (−5.0, 95% CI −7.5 to −2.5) and Group 2 (P/R/R) (−5.9, 95% CI −8.7 to −3.1) reached clinical relevance whereas almost no decrease of symptoms after three periods was seen in Group 3 (R/P/R) (−0.5, 95% CI −2.9 to 1.9).Conclusions Treatment with the complex remedy for 12 or 24 weeks did not result in clinically significant improvement of menopausal symptoms.
DOI:doi:10.3109/13697137.2011.597895
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.3109/13697137.2011.597895
 Volltext: https://doi.org/10.3109/13697137.2011.597895
 DOI: https://doi.org/10.3109/13697137.2011.597895
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:ANTHROPOSOPHICAL MEDICINE
 COMPLEMENTARY THERAPY
 HOMEOPATHY
 MENOPAUSAL SYMPTOMS
 PERIMENOPAUSE
 POSTMENOPAUSE
K10plus-PPN:1577963113
Verknüpfungen:→ Zeitschrift

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