| Online-Ressource |
Verfasst von: | Billing, Heiko [VerfasserIn]  |
| Breil, Thomas [VerfasserIn]  |
| Schmidt, Jan [VerfasserIn]  |
| Tönshoff, Burkhard [VerfasserIn]  |
| Schmitt, Claus P. [VerfasserIn]  |
| Giese, Thomas [VerfasserIn]  |
| Engelmann, Guido [VerfasserIn]  |
Titel: | Pharmacodynamic monitoring by residual NFAT-regulated gene expression in stable pediatric liver transplant recipients |
Verf.angabe: | Heiko Billing, Thomas Breil, Jan Schmidt, Burkhard Tönshoff, Claus Schmitt, Thomas Giese and Guido Engelmann |
E-Jahr: | 2012 |
Jahr: | 24 February 2012 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 26.07.2018 |
Titel Quelle: | Enthalten in: Pediatric transplantation |
Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1999 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 16(2012), 2, Seite 187-194 |
ISSN Quelle: | 1399-3046 |
Abstract: | Billing H, Breil T, Schmidt J, Tönshoff B, Schmitt C, Giese T, Engelmann G. Pharmacodynamic monitoring by residual NFAT-regulated gene expression in stable pediatric liver transplant recipients. Pediatr Transplantation 2012: 16: 187-194. © 2012 John Wiley & Sons A/S. Abstract: Pharmacokinetic monitoring of CNI is unsatisfactory, because at comparable CNI blood concentrations frequency and severity of adverse effects vary considerably among individual patients. Determining the RGE of NFAT-regulated genes in leukocytes is a new pharmacodynamic approach to measure directly the functional consequences of calcineurin inhibition in T-lymphocytes. We compared clinical outcome parameters and RGE of activated T-cells after pLtx. We measured prospectively RGE of NFAT regulated genes in 33 pLTX recipients in the maintenance period after pLTX. CsA-treated patients with recurrent infections had significantly lower RGE rates (27%) than children without recurrent infections (50%; p = 0.04), whereas pharmacokinetic parameters of CsA and the concomitant immunosuppressive therapy were comparable between both groups. In patients on tacrolimus-based IS therapy NFAT RGE was only slightly reduced (90%). Pharmacodynamic monitoring of CsA by measurement of RGE in T-lymphocytes has the potential to identify over-immunosuppressed pediatric liver transplant recipients on a CsA-based IS therapy, while in children on low-dose tacrolimus therapy, RGE measurement does not provide additional clinically useful information. |
DOI: | doi:10.1111/j.1399-3046.2012.01660.x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1111/j.1399-3046.2012.01660.x |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-3046.2012.01660.x |
| DOI: https://doi.org/10.1111/j.1399-3046.2012.01660.x |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | child |
| liver transplantation |
| NFAT |
| pharmacodynamic monitoring |
K10plus-PPN: | 1577968336 |
Verknüpfungen: | → Zeitschrift |
Pharmacodynamic monitoring by residual NFAT-regulated gene expression in stable pediatric liver transplant recipients / Billing, Heiko [VerfasserIn]; 24 February 2012 (Online-Ressource)