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Verfasst von:Billing, Heiko [VerfasserIn]   i
 Breil, Thomas [VerfasserIn]   i
 Schmidt, Jan [VerfasserIn]   i
 Tönshoff, Burkhard [VerfasserIn]   i
 Schmitt, Claus P. [VerfasserIn]   i
 Giese, Thomas [VerfasserIn]   i
 Engelmann, Guido [VerfasserIn]   i
Titel:Pharmacodynamic monitoring by residual NFAT-regulated gene expression in stable pediatric liver transplant recipients
Verf.angabe:Heiko Billing, Thomas Breil, Jan Schmidt, Burkhard Tönshoff, Claus Schmitt, Thomas Giese and Guido Engelmann
E-Jahr:2012
Jahr:24 February 2012
Umfang:8 S.
Fussnoten:Gesehen am 26.07.2018
Titel Quelle:Enthalten in: Pediatric transplantation
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1999
Jahr Quelle:2012
Band/Heft Quelle:16(2012), 2, Seite 187-194
ISSN Quelle:1399-3046
Abstract:Billing H, Breil T, Schmidt J, Tönshoff B, Schmitt C, Giese T, Engelmann G. Pharmacodynamic monitoring by residual NFAT-regulated gene expression in stable pediatric liver transplant recipients. Pediatr Transplantation 2012: 16: 187-194. © 2012 John Wiley & Sons A/S. Abstract: Pharmacokinetic monitoring of CNI is unsatisfactory, because at comparable CNI blood concentrations frequency and severity of adverse effects vary considerably among individual patients. Determining the RGE of NFAT-regulated genes in leukocytes is a new pharmacodynamic approach to measure directly the functional consequences of calcineurin inhibition in T-lymphocytes. We compared clinical outcome parameters and RGE of activated T-cells after pLtx. We measured prospectively RGE of NFAT regulated genes in 33 pLTX recipients in the maintenance period after pLTX. CsA-treated patients with recurrent infections had significantly lower RGE rates (27%) than children without recurrent infections (50%; p = 0.04), whereas pharmacokinetic parameters of CsA and the concomitant immunosuppressive therapy were comparable between both groups. In patients on tacrolimus-based IS therapy NFAT RGE was only slightly reduced (90%). Pharmacodynamic monitoring of CsA by measurement of RGE in T-lymphocytes has the potential to identify over-immunosuppressed pediatric liver transplant recipients on a CsA-based IS therapy, while in children on low-dose tacrolimus therapy, RGE measurement does not provide additional clinically useful information.
DOI:doi:10.1111/j.1399-3046.2012.01660.x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1111/j.1399-3046.2012.01660.x
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-3046.2012.01660.x
 DOI: https://doi.org/10.1111/j.1399-3046.2012.01660.x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:child
 liver transplantation
 NFAT
 pharmacodynamic monitoring
K10plus-PPN:1577968336
Verknüpfungen:→ Zeitschrift

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