Wnt signaling in cancer

• Verfasst von: Zhan, Tianzuo [VerfasserIn]
• Verfasst von: Rindtorff, Niklas [VerfasserIn]
• Verfasst von: Boutros, Michael [VerfasserIn]
• Titel: Wnt signaling in cancer
• Verf.angabe: T. Zhan, N. Rindtorff and M. Boutros
• Jahr: 2017
• Jahr des Originals: 2016
• Umfang: 13 S.
• Fussnoten: Published online 12 September 2016 ; Gesehen am 30.07.2018
• Titel Quelle: Enthalten in: Oncogene
• Ort Quelle: London : Springer Nature, 1997
• Jahr Quelle: 2017
• Band/Heft Quelle: 36(2017), 11, Seite 1461-1473
• ISSN Quelle: 1476-5594
• DOI: doi:10.1038/onc.2016.304
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1578051657

Abstract

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.