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Verfasst von:Kayser, Sabine [VerfasserIn]   i
 Benner, Axel [VerfasserIn]   i
 Krämer, Alwin [VerfasserIn]   i
 Ho, Anthony Dick [VerfasserIn]   i
 Schlenk, Richard Friedrich [VerfasserIn]   i
Titel:Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide
Verf.angabe:S. Kayser, J. Krzykalla, M.A. Elliott, K. Norsworthy, P. Gonzales, R.K. Hills, M.R. Baer, Z. Ráčil, J. Mayer, J. Novak, P. Žák, T. Szotkowski, D. Grimwade, N.H. Russell, R.B. Walter, E H. Estey, J. Westermann, M. Görner, A. Benner, A. Krämer, B.D. Smith, A.K. Burnett, C. Thiede, C. Röllig, A.D. Ho, G. Ehninger, R.F. Schlenk, M.S. Tallman, M.J. Levis and U. Platzbecker
E-Jahr:2017
Jahr:18 April 2017
Umfang:8 S.
Fussnoten:Gesehen am 30.07.2018
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2017
Band/Heft Quelle:31(2017), 11, Seite 2347-2354
ISSN Quelle:1476-5551
Abstract:Therapy-related acute promyelocytic leukemia (t-APL) is relatively rare, with limited data on outcome after treatment with arsenic trioxide (ATO) compared to standard intensive chemotherapy (CTX). We evaluated 103 adult t-APL patients undergoing treatment with all-trans retinoic acid (ATRA) alone (n=7) or in combination with ATO (n=24), CTX (n=53), or both (n=19). Complete remissions were achieved after induction therapy in 57% with ATRA, 100% with ATO/ATRA, 78% with CTX/ATRA, and 95% with CTX/ATO/ATRA. Early death rates were 43% for ATRA, 0% for ATO/ATRA, 12% for CTX/ATRA and 5% for CTX/ATO/ATRA. Three patients relapsed, two developed therapy-related acute myeloid leukemia and 13 died in remission including seven patients with recurrence of the prior malignancy. Median follow-up for survival was 3.7 years. None of the patients treated with ATRA alone survived beyond one year. Event-free survival was significantly higher after ATO-based therapy (95%, 95% CI, 82-99%) as compared to CTX/ATRA (78%, 95% CI, 64-87%; P=0.042), if deaths due to recurrence of the prior malignancy were censored. The estimated 2-year overall survival in intensively treated patients was 88% (95% CI, 80-93%) without difference according to treatment (P=0.47). ATO when added to ATRA or CTX/ATRA is feasible and leads to better outcomes as compared to CTX/ATRA in t-APL.
DOI:doi:10.1038/leu.2017.92
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1038/leu.2017.92
 Volltext: https://www.nature.com/articles/leu201792
 DOI: https://doi.org/10.1038/leu.2017.92
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1578060389
Verknüpfungen:→ Zeitschrift

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