Contrast enhanced ultrasound in mixed hepatocellular cholangiocarcinoma

• Verfasst von: Dong, Yi [VerfasserIn]
• Verfasst von: Teufel, Andreas [VerfasserIn]
• Titel: Contrast enhanced ultrasound in mixed hepatocellular cholangiocarcinoma
• Titelzusatz: case series and review of the literature
• Verf.angabe: Yi Dong, Andreas Teufel, Jörg Trojan, Annalisa Berzigotti, Xin Wu Cui, Christoph F. Dietrich
• Jahr: 2018
• Jahr des Originals: 2017
• Umfang: 7 S.
• Fussnoten: Gesehen am 01.08.2018 ; Available online 24 November 2017
• Titel Quelle: Enthalten in: Digestive and liver disease
• Ort Quelle: [Erscheinungsort nicht ermittelbar] : Saunders, 2000
• Jahr Quelle: 2018
• Band/Heft Quelle: 50(2018), 4, Seite 401-407
• ISSN Quelle: 1878-3562
• DOI: doi:10.1016/j.dld.2017.11.003
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Contrast-enhanced ultrasound (CEUS)
• Sach-SW: Diagnosis
• Sach-SW: Differentiate
• Sach-SW: Mixed hepatocellular cholangiocarcinoma (HCC-CCA)
• K10plus-PPN: 1578153123

Abstract

Background: Mixed hepatocellular cholangiocarcinoma is a rare form of primary liver cancer. Aims: The aim of this study is to report the results of the use of contrast enhanced ultrasound in a series of patients with confirmed mixed hepatocellular cholangiocarcinoma and to provide an updated literature review. Methods: Between January 2012 and October 2016, 25 Asian patients with confirmed mixed hepatocellular cholangiocarcinoma were included in this bicentric retrospective analysis. Clinical data as well recorded images of a standardized conventional B-mode ultrasound and contrast-enhanced ultrasound examination were interpreted by two blinded, independent, experienced radiologists in consensus. Results: All mixed hepatocellular cholangiocarcinoma lesions were heteroechoic on B-mode ultrasound, with ill-defined margins and irregular shapes. Arterial phase hyperenhancement was present in all 25 patients. Late-phase washout and hypoenhancement was present in 24/25 (96%) patients. However, rim-enhancement and early wash-out (which are common in cholangiocellular carcinoma) were found in over 60% of the cases. Conclusion:Contrast-enhanced ultrasound demonstrated findings not typical for HCC in a large proportion of patients with confirmed mixed hepatocellular cholangiocarcinoma. Therefore, histological confirmation is crucial, especially in lesions with atypical findings.