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Status: Bibliographieeintrag

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Verfasst von:Guilhot, Joëlle [VerfasserIn]   i
 Saußele, Susanne [VerfasserIn]   i
 Hehlmann, Rüdiger [VerfasserIn]   i
Titel:Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia
Titelzusatz:a proposal by the European LeukemiaNet
Verf.angabe:Joëlle Guilhot, Michele Baccarani, Richard E. Clark, Francisco Cervantes, François Guilhot, Andreas Hochhaus, Sergei Kulikov, Jiri Mayer, Andreas L. Petzer, Gianantonio Rosti, Philippe Rousselot, Giuseppe Saglio, Susanne Saussele, Bengt Simonsson, Juan-Luis Steegmann, Andrey Zaritskey, Rüdiger Hehlmann
E-Jahr:2012
Jahr:April 16, 2012
Umfang:9 S.
Fussnoten:Prepublished online as Blood First Edition paper, April 16, 2012 ; Gesehen am 03.08.2018
Titel Quelle:Enthalten in: Blood
Ort Quelle:Washington, DC : American Society of Hematology, 1946
Jahr Quelle:2012
Band/Heft Quelle:119(2012), 25, Seite 5963-5971
ISSN Quelle:1528-0020
Abstract:The treatment policy of chronic myeloid leukemia (CML), particularly with tyrosine kinase inhibitors, has been influenced by several recent studies that were well designed and rapidly performed, but their interpretation is of some concern because different end points and methodologies were used. To understand and compare the results of the previous and future studies and to translate their conclusion into clinical practice, there is a need for common definitions and methods for analyses of CML studies. A panel of experts was appointed by the European LeukemiaNet with the aim of developing a set of definitions and recommendations to be used in design, analyses, and reporting of phase 3 clinical trials in this disease. This paper summarizes the consensus of the panel on events and major end points of interest in CML. It also focuses on specific issues concerning the intention-to-treat principle and longitudinal data analyses in the context of long-term follow-up. The panel proposes that future clinical trials follow these recommendations.
DOI:doi:10.1182/blood-2011-10-383711
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1182/blood-2011-10-383711
 kostenfrei: Volltext: http://www.bloodjournal.org/content/119/25/5963
 DOI: https://doi.org/10.1182/blood-2011-10-383711
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1578246202
Verknüpfungen:→ Zeitschrift

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