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Status: Bibliographieeintrag

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Verfasst von:Dongen, Eelco V. van [VerfasserIn]   i
 Zapp, Jascha [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
Titel:Memory stabilization with targeted reactivation during human slow-wave sleep
Verf.angabe:Eelco V. van Dongen, Atsuko Takashima, Markus Barth, Jascha Zapp, Lothar R. Schad, Ken A. Paller, Guillén Fernández
E-Jahr:2012
Jahr:June 12, 2012
Umfang:6 S.
Fussnoten:Gesehen am 07.08.2018
Titel Quelle:Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America
Ort Quelle:Washington, DC : National Acad. of Sciences, 1915
Jahr Quelle:2012
Band/Heft Quelle:109(2012), 26, Seite 10575-10580
ISSN Quelle:1091-6490
Abstract:It is believed that neural representations of recent experiences become reactivated during sleep, and that this process serves to stabilize associated memories in long-term memory. Here, we initiated this reactivation process for specific memories during slow-wave sleep. Participants studied 50 object-location associations with object-related sounds presented concurrently. For half of the associations, the related sounds were re-presented during subsequent slow-wave sleep while participants underwent functional MRI. Compared with control sounds, related sounds were associated with increased activation of right parahippocampal cortex. Postsleep memory accuracy was positively correlated with sound-related activation during sleep in various brain regions, including the thalamus, bilateral medial temporal lobe, and cerebellum. In addition, postsleep memory accuracy was also positively correlated with pre- to postsleep changes in parahippocampal-medial prefrontal connectivity during retrieval of reactivated associations. Our results suggest that the brain is differentially activated by studied and unstudied sounds during deep sleep and that the thalamus and medial temporal lobe are involved in establishing the mnemonic consequences of externally triggered reactivation of associative memories.
DOI:doi:10.1073/pnas.1201072109
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1073/pnas.1201072109
 Kostenfrei: Volltext: http://www.pnas.org/content/109/26/10575
 DOI: https://doi.org/10.1073/pnas.1201072109
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:consolidation
 EEG-functional MRI
 neuroimaging
 replay
K10plus-PPN:157831187X
Verknüpfungen:→ Zeitschrift

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