| |  Online-Ressource |
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| Verfasst von: | Kempf, Anissa [VerfasserIn]  |
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| | Boda, Enrica [VerfasserIn] |
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| | Tews, Björn [VerfasserIn] |
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| Titel: | Control of cell shape, neurite outgrowth, and migration by a Nogo-A/HSPG iInteraction |
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| Verf.angabe: | Anissa Kempf, Enrica Boda, Jessica C.F. Kwok, Rafael Fritz, Valentina Grande, Andrea M. Kaelin, Zorica Ristic, Andre Schmandke, Antonio Schmandke, Bjoern Tews, James W. Fawcett, Olivier Pertz, Annalisa Buffo, Martin E. Schwab |
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| E-Jahr: | 2017 |
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| Jahr: | 21 September 2017 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 07.08.2018 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 43(2017), 1, Seite 24-34 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | Summary Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines via HSPGs. The extracellular, active 180 amino acid Nogo-A region, named Nogo-A-Δ20, binds to heparin and brain-derived heparan sulfate glycosaminoglycans (GAGs) but not to the closely related chondroitin sulfate GAGs. HSPGs are required for Nogo-A-Δ20-induced inhibition of adhesion, cell spreading, and neurite outgrowth, as well as for RhoA activation. Surprisingly, we show that Nogo-A-Δ20 can act via HSPGs independently of its receptor, Sphingosine-1-Phosphate receptor 2 (S1PR2). We thereby identify the HSPG family members syndecan-3 and syndecan-4 as functional receptors for Nogo-A-Δ20. Finally, we show in explant cultures ex vivo that Nogo-A-Δ20 promotes the migration of neuroblasts via HSPGs but not S1PR2. |
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| DOI: | doi:10.1016/j.devcel.2017.08.014 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1016/j.devcel.2017.08.014 |
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| | kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S1534580717306743 |
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| | DOI: https://doi.org/10.1016/j.devcel.2017.08.014 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adhesion |
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| | HSPG |
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| | migration |
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| | neuroblast |
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| | nogo-A |
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| | outgrowth |
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| | RMS |
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| | spreading |
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| | SVZ |
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| | syndecan |
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| K10plus-PPN: | 1578313147 |
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| Verknüpfungen: | → Zeitschrift |
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Control of cell shape, neurite outgrowth, and migration by a Nogo-A/HSPG iInteraction / Kempf, Anissa [VerfasserIn]; 21 September 2017 (Online-Ressource)
