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Verfasst von:Kämmerer, Elke [VerfasserIn]   i
 Renner, Marcus [VerfasserIn]   i
Titel:Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis
Verf.angabe:Elke Kaemmerer, Ursula Schneider, Christina Klaus, Patrick Plum, Andrea Reinartz, Maximilian Adolf, Marcus Renner, Tim G.A.M. Wolfs, Boris W. Kramer, Norbert Wagner, Jan Mollenhauer, Nikolaus Gassler
E-Jahr:2012
Jahr:21 February 2012
Umfang:9 S.
Fussnoten:Gesehen am 07.08.2018
Titel Quelle:Enthalten in: Histopathology
Ort Quelle:Oxford [u.a.] : Wiley-Blackwell, 1977
Jahr Quelle:2012
Band/Heft Quelle:60(2012), 4, Seite 561-569
ISSN Quelle:1365-2559
Abstract:Kaemmerer E, Schneider U, Klaus C, Plum P, Reinartz A, Adolf M, Renner M, Wolfs T G A M, Kramer B W, Wagner N, Mollenhauer J & Gassler N (2012) Histopathology 60, 561-569 Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis Aims: Deleted in malignant brain tumours 1 (DMBT1; gp340) is a secreted glycoprotein which is found in the surface lining epithelia of human small and large intestine. DMBT1 is suggested to play a role in enterocyte differentiation and surface protection from intestinal bacteria. The aim of this study was to elucidate DMBT1 expression in bacteria-related active intestinal inflammation such as appendicitis. Methods and results: mRNA and protein levels of DMBT1 were analysed in surgical resections of 50 appendices (active inflammation: n = 25). In non-actively inflamed appendices, inter-individual differences in basal DMBT1 levels of enterocytes and some non-epithelial cells were found. In active appendicitis, enterocytic DMBT1 mRNA expression was increased approximately fivefold, which was paralleled by a corresponding increase of cytoplasmic and secreted DMBT1 protein levels. Increased DMBT1 expression was predominant in enterocytes adjacent to erosive lesions or ulcers. Conclusions: Our data demonstrate that bacteria-related active inflammation results in a sharp increase of DMBT1 levels in enterocytes. These findings substantiate the view that DMBT1 is of functional relevance for host defence and modulation of the course of intestinal bacteria-related inflammatory responses.
DOI:doi:10.1111/j.1365-2559.2011.04159.x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1111/j.1365-2559.2011.04159.x
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2559.2011.04159.x
 DOI: https://doi.org/10.1111/j.1365-2559.2011.04159.x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:appendicitis
 bacteria recognition
 DMBT1
 enterocyte
 inflammation
K10plus-PPN:1578322820
Verknüpfungen:→ Zeitschrift

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