Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis

• Verfasst von: Kämmerer, Elke [VerfasserIn]
• Verfasst von: Renner, Marcus [VerfasserIn]
• Titel: Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis
• Verf.angabe: Elke Kaemmerer, Ursula Schneider, Christina Klaus, Patrick Plum, Andrea Reinartz, Maximilian Adolf, Marcus Renner, Tim G.A.M. Wolfs, Boris W. Kramer, Norbert Wagner, Jan Mollenhauer, Nikolaus Gassler
• E-Jahr: 2012
• Jahr: 21 February 2012
• Umfang: 9 S.
• Fussnoten: Gesehen am 07.08.2018
• Titel Quelle: Enthalten in: Histopathology
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1977
• Jahr Quelle: 2012
• Band/Heft Quelle: 60(2012), 4, Seite 561-569
• ISSN Quelle: 1365-2559
• DOI: doi:10.1111/j.1365-2559.2011.04159.x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: appendicitis
• Sach-SW: bacteria recognition
• Sach-SW: DMBT1
• Sach-SW: enterocyte
• Sach-SW: inflammation
• K10plus-PPN: 1578322820

Abstract

Kaemmerer E, Schneider U, Klaus C, Plum P, Reinartz A, Adolf M, Renner M, Wolfs T G A M, Kramer B W, Wagner N, Mollenhauer J & Gassler N (2012) Histopathology 60, 561-569 Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis Aims: Deleted in malignant brain tumours 1 (DMBT1; gp340) is a secreted glycoprotein which is found in the surface lining epithelia of human small and large intestine. DMBT1 is suggested to play a role in enterocyte differentiation and surface protection from intestinal bacteria. The aim of this study was to elucidate DMBT1 expression in bacteria-related active intestinal inflammation such as appendicitis. Methods and results: mRNA and protein levels of DMBT1 were analysed in surgical resections of 50 appendices (active inflammation: n = 25). In non-actively inflamed appendices, inter-individual differences in basal DMBT1 levels of enterocytes and some non-epithelial cells were found. In active appendicitis, enterocytic DMBT1 mRNA expression was increased approximately fivefold, which was paralleled by a corresponding increase of cytoplasmic and secreted DMBT1 protein levels. Increased DMBT1 expression was predominant in enterocytes adjacent to erosive lesions or ulcers. Conclusions: Our data demonstrate that bacteria-related active inflammation results in a sharp increase of DMBT1 levels in enterocytes. These findings substantiate the view that DMBT1 is of functional relevance for host defence and modulation of the course of intestinal bacteria-related inflammatory responses.