| Online-Ressource |
Verfasst von: | Kämmerer, Elke [VerfasserIn]  |
| Renner, Marcus [VerfasserIn]  |
Titel: | Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis |
Verf.angabe: | Elke Kaemmerer, Ursula Schneider, Christina Klaus, Patrick Plum, Andrea Reinartz, Maximilian Adolf, Marcus Renner, Tim G.A.M. Wolfs, Boris W. Kramer, Norbert Wagner, Jan Mollenhauer, Nikolaus Gassler |
E-Jahr: | 2012 |
Jahr: | 21 February 2012 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 07.08.2018 |
Titel Quelle: | Enthalten in: Histopathology |
Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1977 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 60(2012), 4, Seite 561-569 |
ISSN Quelle: | 1365-2559 |
Abstract: | Kaemmerer E, Schneider U, Klaus C, Plum P, Reinartz A, Adolf M, Renner M, Wolfs T G A M, Kramer B W, Wagner N, Mollenhauer J & Gassler N (2012) Histopathology 60, 561-569 Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis Aims: Deleted in malignant brain tumours 1 (DMBT1; gp340) is a secreted glycoprotein which is found in the surface lining epithelia of human small and large intestine. DMBT1 is suggested to play a role in enterocyte differentiation and surface protection from intestinal bacteria. The aim of this study was to elucidate DMBT1 expression in bacteria-related active intestinal inflammation such as appendicitis. Methods and results: mRNA and protein levels of DMBT1 were analysed in surgical resections of 50 appendices (active inflammation: n = 25). In non-actively inflamed appendices, inter-individual differences in basal DMBT1 levels of enterocytes and some non-epithelial cells were found. In active appendicitis, enterocytic DMBT1 mRNA expression was increased approximately fivefold, which was paralleled by a corresponding increase of cytoplasmic and secreted DMBT1 protein levels. Increased DMBT1 expression was predominant in enterocytes adjacent to erosive lesions or ulcers. Conclusions: Our data demonstrate that bacteria-related active inflammation results in a sharp increase of DMBT1 levels in enterocytes. These findings substantiate the view that DMBT1 is of functional relevance for host defence and modulation of the course of intestinal bacteria-related inflammatory responses. |
DOI: | doi:10.1111/j.1365-2559.2011.04159.x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1111/j.1365-2559.2011.04159.x |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2559.2011.04159.x |
| DOI: https://doi.org/10.1111/j.1365-2559.2011.04159.x |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | appendicitis |
| bacteria recognition |
| DMBT1 |
| enterocyte |
| inflammation |
K10plus-PPN: | 1578322820 |
Verknüpfungen: | → Zeitschrift |
Increased levels of deleted in malignant brain tumours 1 (DMBT1) in active bacteria-related appendicitis / Kämmerer, Elke [VerfasserIn]; 21 February 2012 (Online-Ressource)