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Status: Bibliographieeintrag

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Verfasst von:Claßen, Laura [VerfasserIn]   i
 Tykocinski, Lars-Oliver [VerfasserIn]   i
 Wiedmann, Felix Tobias [VerfasserIn]   i
 Birr, Carolin [VerfasserIn]   i
 Schiller, Petra [VerfasserIn]   i
 Tucher, Christine [VerfasserIn]   i
 Krienke, Stefan [VerfasserIn]   i
 Raab, Marc-Steffen [VerfasserIn]   i
 Blank, Norbert [VerfasserIn]   i
 Lorenz, Hanns-Martin [VerfasserIn]   i
 Schiller, Martin [VerfasserIn]   i
Titel:Extracellular vesicles mediate intercellular communication
Titelzusatz:transfer of functionally active microRNAs by microvesicles into phagocytes
Verf.angabe:Laura Claßen, Lars-Oliver Tykocinski, Felix Wiedmann, Carolin Birr, Petra Schiller, Christine Tucher, Stefan Krienke, Marc-Steffen Raab, Norbert Blank, Hanns-Martin Lorenz and Martin Schiller
E-Jahr:2017
Jahr:30 June 2017
Umfang:15 S.
Fussnoten:Gesehen am 07.08.2018
Titel Quelle:Enthalten in: European journal of immunology
Ort Quelle:Weinheim : Wiley-VCH, 1971
Jahr Quelle:2017
Band/Heft Quelle:47(2017), 9, Seite 1535-1549
ISSN Quelle:1521-4141
Abstract:Cell activation and apoptosis lead to the formation of extracellular vesicles (EVs) such as exosomes or microvesicles (MVs). EVs have been shown to modulate immune responses; recently, MVs were described to carry microRNA (miRNA) and a role for MVs in the pathogenesis of autoimmune diseases has been discussed. Here we systematically characterized MVs and exosomes according to their release stimuli. The miRNA content of viable or apoptotic human T lymphocytes and the corresponding MVs was analyzed. miRNA, protein and surface marker expression, as well as cytokine release by human monocytes was measured after EV engulfment. Finally, miRNA expression in T lymphocytes and MVs of healthy individuals was compared with those of systemic lupus erythematosus (SLE) patients. We demonstrate that, depending on the stimuli, distinct subtypes of EVs are released, differing in size and carrying a specific RNA profile. We observed an accumulation of distinct miRNAs in MVs after induction of apoptosis and the transfer of functional miRNA by MVs into human monocytes. MVs released from apoptotic cells provoke less of an inflammatory response than those released from viable cells. MiR-155*, miR-34b and miR-34a levels in T lymphocytes and corresponding MVs were deregulated in SLE when compared to healthy individuals.
DOI:doi:10.1002/eji.201646595
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1002/eji.201646595
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201646595
 DOI: https://doi.org/10.1002/eji.201646595
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Apoptosis
 Autoimmune disease
 MicroRNA
 Microvesicles
 SLE
K10plus-PPN:1578323827
Verknüpfungen:→ Zeitschrift

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