Terpenoids with potent antimycobacterial activity against Mycobacterium tuberculosis from Trigonostemon reidioides roots

• Verfasst von: Kaemchantuek, Praphakorn [VerfasserIn]
• Verfasst von: Chamulitrat, Walee [VerfasserIn]
• Titel: Terpenoids with potent antimycobacterial activity against Mycobacterium tuberculosis from Trigonostemon reidioides roots
• Verf.angabe: Praphakorn Kaemchantuek, Ratchanaporn Chokchaisiri, Samran Prabpai, Palangpon Kongsaeree, Warangkana Chunglok, Tanyarath Utaipan, Walee Chamulitrat, Apichart Suksamrarn
• E-Jahr: 2017
• Jahr: 4 February 2017
• Umfang: 8 S.
• Fussnoten: Gesehen am 07.08.2018
• Titel Quelle: Enthalten in: Tetrahedron
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1957
• Jahr Quelle: 2017
• Band/Heft Quelle: 73(2017), 12, Seite 1594-1601
• ISSN Quelle: 1464-5416
• DOI: doi:10.1016/j.tet.2017.02.006
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antimycobacterial activity
• Sach-SW: Diterpenoids
• K10plus-PPN: 1578332567

Abstract

Phytochemical investigation of Trigonostemon reidioides roots led to the isolation of fourteen compounds. These included six new diterpenoids, trigonoreidons A−F (1−6), together with eight known diterpenoids 7−14. The structures of the new compounds were elucidated by spectroscopic techniques and the absolute configuration at the asymmetric carbon was determined by the modified Mosher's method. The structure of trigonoreidon B (2) was confirmed by X-ray crystallographic analysis. The known compounds were identified by comparison of the spectroscopic and physical data with those of reported values. The isolated compounds were evaluated for antimycobacterial activity against Mycobacterium tuberculosis. Among the compounds that exhibited antimycobacterial activity, the diterpenoids rediocide C (12) and rediocide G (14) were the most active compounds, with the MIC value of 3.84 μM.