Hereditäres kolorektales Karzinom

• Verfasst von: Kadmon, Martina [VerfasserIn]
• Verfasst von: Kloor, Matthias [VerfasserIn]
• Verfasst von: Tariverdian, Mirjam [VerfasserIn]
• Titel: Hereditäres kolorektales Karzinom
• Titelzusatz: effiziente Primärprävention
• Verf.angabe: M. Kadmon, M. Kloor, M. Tariverdian
• Jahr: 2012
• Jahr des Originals: 2011
• Umfang: 9 S.
• Fussnoten: Gesehen am 07.08.2018 ; Published online first: 06 July 2011
• Titel Quelle: Enthalten in: Der Onkologe
• Ort Quelle: Berlin : Springer, 1996
• Jahr Quelle: 2012
• Band/Heft Quelle: 18(2012), 3, Seite 207-215
• ISSN Quelle: 1433-0415
• DOI: doi:10.1007/s00761-011-2090-0
• Datenträger: Online-Ressource
• Sprache: ger
• K10plus-PPN: 157835191X

Abstract

Genetically defined hereditary colorectal cancer affects mostly young patients and their families and accounts for approximately 3-5% of all colorectal cancers. Early detection and clinical management determine the prognosis and are the responsibility of clinicians. While the classical variant of familial adenomatous polyposis (FAP) is characterized by a distinct phenotype, Lynch syndrome, attenuated FAP (aFAP) and MUTYH-associated adenomatous polyposis (MAP) show phenotypic overlaps which render unequivocal classification difficult. The present article elucidates the clinical manifestations, current surveillance concepts and preventive operative strategies in patients with hereditary tumor predisposition syndromes and their families.