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Verfasst von:Claus, Juliane [VerfasserIn]   i
 Chavarría-Krauser, Andrés [VerfasserIn]   i
Titel:Modeling regulation of zinc uptake via ZIP transporters in east and plant roots
Verf.angabe:Juliane Claus, Andrés Chavarría-Krauser
E-Jahr:2012
Jahr:June 8, 2012
Umfang:11 S.
Fussnoten:Gesehen am 08.08.2018
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2012
Band/Heft Quelle:7(2012), 6, Artikel-ID 37193, Seite 1-11
ISSN Quelle:1932-6203
Abstract:In yeast (Saccharomyces cerevisiae) and plant roots (Arabidopsis thaliana) zinc enters the cells via influx transporters of the ZIP family. Since zinc is both essential for cell function and toxic at high concentrations, tight regulation is essential for cell viability. We provide new insight into the underlying mechanisms, starting from a general model based on ordinary differential equations and adapting it to the specific cases of yeast and plant root cells. In yeast, zinc is transported by the transporters ZRT1 and ZRT2, which are both regulated by the zinc-responsive transcription factor ZAP1. Using biological data, parameters were estimated and analyzed, confirming the different affinities of ZRT1 and ZRT2 reported in the literature. Furthermore, our model suggests that the positive feedback in ZAP1 production has a stabilizing function at high influx rates. In plant roots, various ZIP transporters play a role in zinc uptake. Their regulation is largely unknown, but bZIP transcription factors are thought to be involved. We set up three putative models based on: an activator only, an activator with dimerization and an activator-inhibitor pair. These were fitted to measurements and analyzed. Simulations show that the activator-inhibitor model outperforms the other two in providing robust and stable homeostasis at reasonable parameter ranges.
DOI:doi:10.1371/journal.pone.0037193
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext ; Verlag: http://dx.doi.org/10.1371/journal.pone.0037193
 kostenfrei: Volltext: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037193
 DOI: https://doi.org/10.1371/journal.pone.0037193
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Dimerization
 Homeostasis
 Micronutrient deficiencies
 Plant roots
 Transcription factors
 Transcriptional control
 Yeast and fungal models
 Zinc
K10plus-PPN:1578363810
Verknüpfungen:→ Zeitschrift

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