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Verfasst von:Send, Tabea [VerfasserIn]   i
 Sütterlin, Marc [VerfasserIn]   i
 Laucht, Manfred [VerfasserIn]   i
 Deuschle, Michael [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
 Witt, Stephanie [VerfasserIn]   i
Titel:Telomere length in newborns is related to maternal stress during pregnancy
Verf.angabe:Tabea Sarah Send, Maria Gilles, Veryan Codd, Isabell Wolf, Svenja Bardtke, Fabian Streit, Jana Strohmaier, Josef Frank, Darja Schendel, Mark W. Sütterlin, Matthew Denniff, Manfred Laucht, Nilesh J. Samani, Michael Deuschle, Marcella Rietschel and Stephanie H. Witt
E-Jahr:2017
Jahr:11 April 2017
Umfang:7 S.
Fussnoten:Gesehen am 08.08.2018
Titel Quelle:Enthalten in: Neuropsychopharmacology
Ort Quelle:London : Springer Nature, 1993
Jahr Quelle:2017
Band/Heft Quelle:42(2017), 12, Seite 2407-2413
ISSN Quelle:1740-634X
Abstract:Telomere length (TL) is a marker of biological aging, and numerous studies have shown associations between TL and somatic or psychiatric disorders. Research also indicates an association between maternal stress during pregnancy and TL in the offspring. The present study investigated possible associations between TL and: (1) maternal perceived stress during pregnancy; (2) a maternal lifetime history of psychiatric disorder (lifetime PD); and (3) paternal age. TL was analyzed in 319 newborns and 318 mothers from a predominantly Caucasian sample (n=273 Caucasian newborns and n=274 Caucasian mothers). Two key findings were observed. First, maternal perceived stress during pregnancy was associated with shorter telomeres in newborns but not with maternal TL. Second, maternal lifetime PD was associated with shorter maternal telomeres, but not with TL in newborns. Paternal age was not associated with TL in newborns. The finding that maternal stress during pregnancy is associated with shorter telomeres in newborns supports the results of smaller previous studies. The fact that a relation between maternal prenatal stress and TL was observed in the offspring but not in mothers may be attributable to a high vulnerability to stress during intrauterine development of a maturing organism. To our knowledge, this is the largest study to date to show that maternal stress during pregnancy but not maternal lifetime PD is associated with shorter telomeres in the offspring.
DOI:doi:10.1038/npp.2017.73
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1038/npp.2017.73
 DOI: https://doi.org/10.1038/npp.2017.73
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1578377900
Verknüpfungen:→ Zeitschrift

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