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Verfasst von:Gorkom, Gwendolyn van [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
Titel:Prospective noninterventional study on peripheral blood stem cell mobilization in patients with relapsed lymphomas
Verf.angabe:Gwendolyn van Gorkom, Herve Finel, Sebastian Giebel, David Pohlreich, Avichai Shimoni, Mark Ringhoffer, Gülsan Sucak, Nicolaas Schaap, Peter Dreger, Anna Sureda, Harry C. Schouten
Jahr des Originals:2016
Umfang:7 S.
Fussnoten:Published online: 18 August 2016 ; Gesehen am 09.08.2018
Titel Quelle:Enthalten in: Journal of clinical apheresis
Jahr Quelle:2017
Band/Heft Quelle:32(2017), 5, S. 295-301
ISSN Quelle:1098-1101
Abstract:High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) to rescue hematopoiesis is considered standard care for patients with a relapsed chemosensitive lymphoma, but diagnosis of lymphoma has been a risk factor for poor mobilization in several studies. The aim of this prospective noninterventional clinical audit was to review the mobilization strategies used by EBMT centers in relapsed lymphoma and to evaluate their efficacy. Between 2010 and 2014, 275 patients with relapsed lymphoma from 30 EBMT centers were prospectively registered. Almost all patients were mobilized with chemotherapy plus G-CSF (96%), but there was a large variation in chemotherapy schedules. Thirty (11%) of them were poor mobilizers (<2 × 106 CD 34+ cells/kg body weight) at the first mobilization. Poor mobilization was not associated with gender, age, bone marrow involvement at diagnosis, primary diagnosis, number of previous chemotherapy lines, previous radiotherapy or mobilization with G-CSF alone. The use of high dose cyclophosphamide alone was associated with mobilization failure (P = 0.0006), whereas the use of a platinum-containing regimen was associated with a good mobilization outcome (P = 0.013). Because failure rate is low, we can conclude from this study that PBSC mobilization failure in relapsed lymphomas is not an important problem in the EBMT centers.
DOI:doi:10.1002/jca.21506
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1002/jca.21506
 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1002/jca.21506
 DOI: https://doi.org/10.1002/jca.21506
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1578417740
Verknüpfungen:→ Zeitschrift

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