| |  Online-Ressource |
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| Verfasst von: | Tan, Linette Liqi [VerfasserIn]  |
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| | Pelzer, Patric [VerfasserIn] |
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| | Heinl, Céline [VerfasserIn] |
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| | Gangadharan, Vijayan [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Sprengel, Rolf [VerfasserIn] |
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| | Kuner, Thomas [VerfasserIn] |
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| | Kuner, Rohini [VerfasserIn] |
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| Titel: | A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity |
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| Verf.angabe: | Linette Liqi Tan, Patric Pelzer, Céline Heinl, Wannan Tang, Vijayan Gangadharan, Herta Flor, Rolf Sprengel, Thomas Kuner and Rohini Kuner |
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| E-Jahr: | 2017 |
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| Jahr: | 18 September 2017 |
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| Umfang: | 11 S. |
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| Fussnoten: | Published: 18 September 2017 ; Gesehen am 09.08.2018 |
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| Titel Quelle: | Enthalten in: Nature neuroscience |
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| Ort Quelle: | New York, NY : Nature America, 1998 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 20(2017), 11, Seite 1591-1601 |
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| ISSN Quelle: | 1546-1726 |
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| Abstract: | The identity of cortical circuits mediating nociception and pain is largely unclear. The cingulate cortex is consistently activated during pain, but the functional specificity of cingulate divisions, the roles at distinct temporal phases of central plasticity and the underlying circuitry are unknown. Here we show in mice that the midcingulate division of the cingulate cortex (MCC) does not mediate acute pain sensation and pain affect, but gates sensory hypersensitivity by acting in a wide cortical and subcortical network. Within this complex network, we identified an afferent MCC-posterior insula pathway that can induce and maintain nociceptive hypersensitivity in the absence of conditioned peripheral noxious drive. This facilitation of nociception is brought about by recruitment of descending serotonergic facilitatory projections to the spinal cord. These results have implications for our understanding of neuronal mechanisms facilitating the transition from acute to long-lasting pain. |
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| DOI: | doi:10.1038/nn.4645 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1038/nn.4645 |
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| | Volltext: http://www-nature-com/articles/nn.4645 |
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| | DOI: https://doi.org/10.1038/nn.4645 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1578440777 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity / Tan, Linette Liqi [VerfasserIn]; 18 September 2017 (Online-Ressource)
