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Verfasst von:Lengfelder, Eva [VerfasserIn]   i
 Hofmann, Wolf-Karsten [VerfasserIn]   i
 Nowak, Daniel [VerfasserIn]   i
Titel:Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia
Verf.angabe:E. Lengfelder, W.-K. Hofmann and D. Nowak
Jahr:2012
Jahr des Originals:2011
Umfang:10 S.
Fussnoten:Published: 09 September 2011 ; Gesehen am 10.08.2018
Titel Quelle:Enthalten in: Leukemia
Ort Quelle:London : Springer Nature, 1997
Jahr Quelle:2012
Band/Heft Quelle:26(2012), 3, Seite 433-442
ISSN Quelle:1476-5551
Abstract:Arsenic trioxide (ATO) is presently the most active single agent in the treatment of acute promyelocytic leukemia (APL). This review provides insights into the mode of action and the pharmacological properties of ATO, and summarizes the most relevant results of more than 20 treatment studies in relapsed or newly diagnosed APL published between 1997 and 2011. ATO acts by targeting multiple pathways in APL leading to apoptosis and myeloid differentiation. It induces complete remission without myelosuppression and causes only few adverse effects. In relapsed APL, ATO-based salvage therapy has been able to induce long-lasting remissions and possible cure in 50–81% of patients. In newly diagnosed APL, two main strategies are currently pursued. ATO is either included into induction therapy with the aim to minimize or eliminate chemotherapy, or it is incorporated as an additive into established first-line concepts with all-trans-retinoic acid and chemotherapy to reinforce their anti-leukemic efficacy. Recent results suggest a high efficacy of ATO in both concepts. In conclusion, experimental research and clinical studies have made contributions toward a better understanding of the molecular mechanisms induced by ATO in APL cells and have established this historic substance as an important candidate for the further improvement of APL therapy.
DOI:doi:10.1038/leu.2011.245
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1038/leu.2011.245
 Volltext: https://www.nature.com/articles/leu2011245
 DOI: https://doi.org/10.1038/leu.2011.245
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1578471494
Verknüpfungen:→ Zeitschrift

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