| |  Online-Ressource |
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| Verfasst von: | Jungbauer, Frederic  |
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| | Aderhold, Marc Christoph [VerfasserIn] |
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| | Birk, Richard [VerfasserIn] |
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| | Hörmann, Karl [VerfasserIn] |
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| | Kramer, Benedikt [VerfasserIn] |
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| | Walter, Beatrice [VerfasserIn] |
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| | Thorn, Carsten Volker [VerfasserIn] |
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| | Lammert, Anne [VerfasserIn] |
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| Titel: | Communicate or die |
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| Titelzusatz: | a model for HPV+ and HPV− CSCs and their interactions with SDF-1α |
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| Verf.angabe: | Frederic Jungbauer, Christoph Aderhold, Richard Birk, Karl Hoermann, Benedikt Kramer, Beatrice Kuhlin, Carsten Thorn, Claudia Umbreit and Anne Lammert |
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| Jahr: | 2017 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 13.08.2018 |
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| Titel Quelle: | Enthalten in: Anticancer research |
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| Ort Quelle: | Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 37(2017), 9, Seite 4827-4836 |
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| ISSN Quelle: | 1791-7530 |
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| Abstract: | Background/Aim: Cancer stem cells (CSCs) are suspected of being a reason for limited therapy in head and neck squamous cell carcinoma (HNSCC). Stromal cell-derived factor-1 alpha (SDF-1 alpha) plays a critical role in the communication between CSCs and their microenvironment. We investigated the influence of SDF-1 alpha on HPV+/HPV-SCC cell lines to find an approach of explanation for the superior prognosis of HPV+ HNSCCs. Materials and Methods: We evaluated the expression of CD44/CXCR4 on HPV+/HPV- SCC cell lines and monitored the influence of SDF-1 alpha on proliferation, morphology and migration of HPV+/HPV- SCCs. Results: HPV- SCCs showed a significant increase of podia formation and an intensified migration towards SDF-1 alpha. HPV+ SCCs rested nearly unaffected by SDF-1 alpha. Conclusion: Weakened reaction to SDF-1 alpha in HPV+ SCC could lead to an impaired communication between CSCs and their niche, that would result in an increased exposure of CSCs to the harming influence of e.g. chemotherapeutic agents. |
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| DOI: | doi:10.21873/anticanres.11890 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.21873/anticanres.11890 |
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| | Volltext: http://ar.iiarjournals.org/content/37/9/4827.abstract |
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| | DOI: https://doi.org/10.21873/anticanres.11890 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1578517338 |
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| Verknüpfungen: | → Zeitschrift |
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