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Status: Bibliographieeintrag

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Verfasst von:Askoxylakis, Vasileios [VerfasserIn]   i
 Dinkel, Julien [VerfasserIn]   i
 Eichinger, Monika [VerfasserIn]   i
 Strauss, Ludwig G. [VerfasserIn]   i
 Dimitrakopoulou-Strauss, Antonia [VerfasserIn]   i
 Kopp-Schneider, Annette [VerfasserIn]   i
 Haberkorn, Uwe [VerfasserIn]   i
 Huber, Peter E. [VerfasserIn]   i
 Bischof, Marc [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Thieke, Christian [VerfasserIn]   i
Titel:Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer
Titelzusatz:the HIL trial
Verf.angabe:Vasileios Askoxylakis, Julien Dinkel, Monika Eichinger, Bram Stieltjes, Gregor Sommer, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Annette Kopp-Schneider, Uwe Haberkorn, Peter E. Huber, Marc Bischof, Jürgen Debus and Christian Thieke
E-Jahr:2012
Jahr:14 September 2012
Umfang:7 S.
Fussnoten:Gesehen am 15.08.2018
Titel Quelle:Enthalten in: Radiation oncology
Ort Quelle:London : BioMed Central, 2006
Jahr Quelle:2012
Band/Heft Quelle:7(2012) Artikel-Nummer 157, 7 Seiten
ISSN Quelle:1748-717X
Abstract:BACKGROUND: Radiotherapy, preferably combined with chemotherapy, is the treatment standard for locally advanced, unresectable non-small cell lung cancer (NSCLC). The tumor response to different therapy protocols is variable, with hypoxia known to be a major factor that negatively influences treatment effectiveness. Visualisation of tumor hypoxia prior to the use of modern radiation therapy strategies, such as intensity modulated radiation therapy (IMRT), might allow optimized dose applications to the target volume, leading to improvement of therapy outcome. (18)F-fluoromisonidazole dynamic positron emission tomography and computed tomography ((18) F-FMISO dPET-CT) and functional magnetic resonance imaging (functional MRI) are attractive options for imaging tumor hypoxia. METHODS/DESIGN: The HIL trial is a single centre study combining multimodal hypoxia imaging with (18) F-FMISO dPET-CT and functional MRI, with intensity modulated radiation therapy (IMRT) in patients with inoperable stage III NSCLC. 15 patients will be recruited in the study. All patients undergo initial FDG PET-CT and serial (18) F-FMISO dPET-CT and functional MRI before treatment, at week 5 of radiotherapy and 6 weeks post treatment. Radiation therapy is performed as inversely planned IMRT based on 4D-CT. DISCUSSION: Primary objectives of the trial are to characterize the correlation of (18) F-FMISO dPET-CT and functional MRI for tumor hypoxia imaging in NSCLC and evaluate possible effects of radiation therapy on tumor re-oxygenation. Further objectives include the generation of data regarding the prognostic value of (18) F-FMISO dPET-CT and functional MRI for locoregional control, progression free survival and overall survival of NSCLC treated with IMRT, which will form the basis for larger clinical trials focusing on possible interactions between tumor oxygenation and radiotherapy outcome. TRIAL REGISTRATION: The ClinicalTrials.gov protocol ID is NCT01617980.
DOI:doi:10.1186/1748-717X-7-157
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Kostenfrei: Volltext: http://dx.doi.org/10.1186/1748-717X-7-157
 DOI: https://doi.org/10.1186/1748-717X-7-157
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Algorithms
 Carcinoma, Non-Small-Cell Lung
 Humans
 Hypoxia
 Lung Neoplasms
 Magnetic Resonance Imaging
 Misonidazole
 Multimodal Imaging
 Neoplasm Staging
 Positron-Emission Tomography
 Radiation-Sensitizing Agents
 Radiotherapy Planning, Computer-Assisted
 Radiotherapy, Intensity-Modulated
 Salvage Therapy
 Tomography, X-Ray Computed
 Treatment Outcome
K10plus-PPN:1580060994
Verknüpfungen:→ Zeitschrift

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