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Status: Bibliographieeintrag

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Verfasst von:Waltereit, Robert [VerfasserIn]   i
 Schneider, Miriam [VerfasserIn]   i
 Endris, Volker [VerfasserIn]   i
 Bacon, Claire [VerfasserIn]   i
 Rappold, Gudrun [VerfasserIn]   i
 Wieland, Thomas [VerfasserIn]   i
 Bartsch, Dusan [VerfasserIn]   i
Titel:Srgap3−/− mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes
Verf.angabe:Robert Waltereit, Uwe Leimer, Oliver von Bohlen und Halbach, Jutta Panke, Sabine M. Hölter, Lillian Garrett, Karola Wittig, Miriam Schneider, Camie Schmitt, Julia Calzada-Wack, Frauke Neff, Lore Becker, Cornelia Prehn, Sergej Kutscherjawy, Volker Endris, Claire Bacon, Helmut Fuchs, Valérie Gailus-Durner, Stefan Berger, Kai Schönig, Jerzy Adamski, Thomas Klopstock, Irene Esposito, Wolfgang Wurst, Martin Hrabě de Angelis, Gudrun Rappold, Thomas Wieland, and Dusan Bartsch
E-Jahr:2012
Jahr:20 Jul 2012
Umfang:11 S.
Fussnoten:Published online 20 July 2012 ; Gesehen am 15.08.2018
Titel Quelle:Enthalten in: Federation of American Societies for Experimental BiologyThe FASEB journal
Ort Quelle:Hoboken, NJ : Wiley, 1987
Jahr Quelle:2012
Band/Heft Quelle:26(2012), 11, Seite 4418-4428
ISSN Quelle:1530-6860
Abstract:Mutations in the SRGAP3 gene residing on chromosome 3p25 have previously been associated with intellectual disability. Genome-wide association studies have also revealed SRGAP3, together with genes from the same cellular network, as risk genes for schizophrenia. SRGAP3 regulates cytoskeletal dynamics through the RHO protein RAC1. RHO proteins are known to be involved in cytoskeletal reorganization during brain development to control processes such as synaptic plasticity. To elucidate the importance of SRGAP3 in brain development, we generated Srgap3-knockout mice. Ten percent of these mice developed a hydrocephalus and died before adulthood. Surviving mice showed various neuroanatomical changes, including enlarged lateral ventricles, white matter tracts, and dendritic spines together with molecular changes, including an increased basal activity of RAC1. Srgap3−/− mice additionally exhibited a complex behavioral phenotype. Behavioral studies revealed an impaired spontaneous alternation and social behavior, while long-term memory was unchanged. The animals also had tics. Lower locomotor activity was observed in male Srgap3−/− only. Srgap3−/− mice showed increased methylphenidate stimulation in males and an impaired prepulse inhibition in females. Together, the results show neurodevelopmental aberration in Srgap3−/− mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders.—Waltereit, R., Leimer, U., von Bohlen und Halbach, O., Panke, J., Hölter, S. M., Garrett, L., Wittig, K., Schneider, M., Schmitt, C., Calzada-Wack, J., Neff, F., Becker, L., Prehn, C., Kutscherjawy, S., Endris, V., Bacon, C., Fuchs, H., Gailus-Durner, V., Berger, S., Schönig, K., Adamski, J., Klopstock, T., Esposito, I., Wurst, W., Hrabě de Angelis, M., Rappold, G., Wieland, T., Bartsch, D. Srgap3−/− mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.
DOI:doi:10.1096/fj.11-202317
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1096/fj.11-202317
 Volltext: https://www-fasebj-org.ezproxy.medma.uni-heidelberg.de/doi/10.1096/fj.11-202317
 DOI: https://doi.org/10.1096/fj.11-202317
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1580069762
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