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Verfasst von:Peyrot, Wouter [VerfasserIn]   i
 Strohmaier, Jana [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
Titel:Does childhood trauma moderate polygenic risk for depression?
Titelzusatz:a meta-analysis of 5765 subjects from the psychiatric genomics consortium
Verf.angabe:Wouter J. Peyrot, Sandra Van der Auwera, Yuri Milaneschi, Conor V. Dolan, Pamela A.F. Madden, Patrick F. Sullivan, Jana Strohmaier, Stephan Ripke, Marcella Rietschel, Michel G. Nivard, Niamh Mullins, Grant W. Montgomery, Anjali K. Henders, Andrew C. Heat, Helen L. Fisher, Erin C. Dunn, Enda M. Byrne, Tracy A. Air, Bernhard T. Baune, Gerome Breen, Douglas F. Levinson, Cathryn M. Lewis, Nick G. Martin, Elliot N. Nelson, Dorret I. Boomsma, Hans J. Grabe, Naomi R. Wray, and Brenda W.J.H. Penninx
Jahr:2018
Jahr des Originals:2017
Umfang:10 S.
Fussnoten:Published online: 21 September 2017 ; Gesehen am 16.08.2018
Titel Quelle:Enthalten in: Biological psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1985
Jahr Quelle:2018
Band/Heft Quelle:84(2018), 2, Seite 138-147
ISSN Quelle:1873-2402
Abstract:Background The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. Methods Data were combined from 3024 MDD cases and 2741 control subjects from nine cohorts contributing to the MDD Working Group of the Psychiatric Genomics Consortium. MDD-PRS were based on a discovery sample of ∼110,000 independent individuals. CT was assessed as exposure to sexual or physical abuse during childhood. In a subset of 1957 cases and 2002 control subjects, a more detailed five-domain measure additionally included emotional abuse, physical neglect, and emotional neglect. Results MDD was associated with the MDD-PRS (odds ratio [OR] = 1.24, p = 3.6 × 10−5, R2 = 1.18%) and with CT (OR = 2.63, p = 3.5 × 10−18 and OR = 2.62, p = 1.4 ×10−5 for the two- and five-domain measures, respectively). No interaction was found between MDD-PRS and the two-domain and five-domain CT measure (OR = 1.00, p = .89 and OR = 1.05, p = .66). Conclusions No meta-analytic evidence for interaction between MDD-PRS and CT was found. This suggests that the previously reported interaction effects, although both statistically significant, can best be interpreted as chance findings. Further research is required, but this study suggests that the genetic heterogeneity of MDD is not attributable to genome-wide moderation of genetic effects by CT.
DOI:doi:10.1016/j.biopsych.2017.09.009
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.biopsych.2017.09.009
 Volltext: http://www.sciencedirect.com/science/article/pii/S0006322317319935
 DOI: https://doi.org/10.1016/j.biopsych.2017.09.009
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Childhood trauma
 Depression
 Genetics
 Interaction
 Meta-analysis
 Polygenic risk
K10plus-PPN:1580100368
Verknüpfungen:→ Zeitschrift

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