Dynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts

• Verfasst von: Khodosevich, Konstantin [VerfasserIn]
• Verfasst von: Alfonso, Julieta [VerfasserIn]
• Verfasst von: Monyer, Hannah [VerfasserIn]
• Titel: Dynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts
• Verf.angabe: Konstantin Khodosevich, Julieta Alfonso, Hannah Monyer
• Jahr: 2013
• Jahr des Originals: 2012
• Umfang: 9 S.
• Fussnoten: Available online 5 December 2012 ; Gesehen am 16.08.2018
• Titel Quelle: Enthalten in: Mechanisms of development
• Ort Quelle: Shannon : Elsevier, 1990
• Jahr Quelle: 2013
• Band/Heft Quelle: 130(2013), 6, Seite 424-432
• ISSN Quelle: 1872-6356
• DOI: doi:10.1016/j.mod.2012.11.003
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Differentiation
• Sach-SW: Gene expression
• Sach-SW: Migration
• Sach-SW: Neuroblasts
• Sach-SW: Proliferation
• Sach-SW: Subventricular zone
• K10plus-PPN: 1580107729

Abstract

The subventricular zone (SVZ) of the lateral ventricles is a major neurogenic region in the postnatal mammalian brain. Thousands of neuroblasts are generated daily throughout the life of an animal. Newly born neuroblasts migrate via the rostral migratory stream (RMS) into the olfactory bulb where they mature into distinct neuronal subtypes. Neuroblasts exiting the SVZ retain the ability to proliferate, however, proliferation declines in the course of migration to the olfactory bulb. While migrating in the RMS, neuroblasts receive a plethora of stimuli that modify transcription according to the local microenvironment, and eventually modulate neuroblast migration. In the target area, the olfactory bulb, neuroblasts develop into mature neurons. In this review, we discuss dynamic changes of the transcriptome that occur during the “lifetime” of a neuroblast, thereby governing the activation or inhibition of distinct genes/pathways that are responsible for proliferation, migration and differentiation.