Organ preservation is less frequently performed in women surgically treated for papillary renal cell carcinoma

• Verfasst von: Wolff, Ingmar [VerfasserIn]
• Verfasst von: Wagener, Nina [VerfasserIn]
• Titel: Organ preservation is less frequently performed in women surgically treated for papillary renal cell carcinoma
• Titelzusatz: results of a comprehensive multicenter study
• Verf.angabe: Ingmar Wolff, Anna Scavuzzo, Umberto Capitanio, Tobias Klatte, Shahrokh F. Shariat, Nina Wagener, Stefan Zastrow, Hendrik Borgmann, Laura-Maria Krabbe, Georg Hutterer, Matthias May, Sabine D. Brookman-May, Luca Cindolo, Thorsten Ecke, Axel Haferkamp, Edwin Herrmann, Markus Hohenfellner, Milan Hora, Bernd Hoschke, Nina Huck, Miguel Angel Jimenez Rios, Cristian Mirvald, Mireia Musquera, Paolo Dell'Oglio, Sascha Pahernik, Krystina Prochazkova, Nancy Reynoso-Noverón, Christian G. Stief, Cristian Surcel, Daniel Vergho, Raphaela Waidelich, Manfred Wirth, Richard Zigeuner
• E-Jahr: 2017
• Jahr: November 2017
• Umfang: 8 S.
• Fussnoten: Gesehen am 16.08.2018
• Titel Quelle: Enthalten in: Urology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1973
• Jahr Quelle: 2017
• Band/Heft Quelle: 109(2017), Seite 107-114
• ISSN Quelle: 1527-9995
• DOI: doi:10.1016/j.urology.2017.06.042
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1580115241

Abstract

Objective: To analyze the impact of gender on the clinicopathologic features and survival of patients with surgically treated papillary renal cell carcinoma (papRCC) using a comprehensive international multicenter database. Materials and Methods: Data of 2325 patients undergoing surgery for unilateral papRCC between 1984 and 2015 in 17 European and North American centers were retrospectively collated. The impact of clinicopathologic features on the likelihood of nephron-sparing surgery (NSS) was evaluated using a multivariable logistic regression model. The influence on cancer-specific mortality (CSM) and other-cause mortality was analyzed by multivariable competing-risk regression models. Finally, subgroup analyses were conducted for organ-confined (n = 2075) and non-organ-confined tumors (n = 250). The median follow-up was 47 months. Results: The study cohort included 1782 (77%) male patients (male-to-female ratio 3.3:1.0). Considering age, symptoms at presentation, performance status, pathologic tumor size, stage, and grade, we observed that there were no significant gender-specific differences. In contrast, female patients underwent NSS significantly less frequently (P <.001). On multivariable analysis, the likelihood of NSS was 72% higher in male patients after adjusting for all relevant cofactors (P <.001). No significant gender-specific differences in terms of CSM and other-cause mortality were demonstrated, but CSM was 59% lower in female patients in the subgroup of organ-confined tumors (P = .001). Conclusion: No impact of gender on survival was found analyzing this large cohort of patients undergoing surgery for papRCC. However, CSM appears to be lower in female patients with organ-confined disease. In this context, it is interesting that the likelihood of NSS seems to be significantly higher in male patients.