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Verfasst von:Guschanski, Katerina [VerfasserIn]   i
 Warnefors, Maria [VerfasserIn]   i
 Kaessmann, Henrik [VerfasserIn]   i
Titel:The evolution of duplicate gene expression in mammalian organs
Verf.angabe:Katerina Guschanski, Maria Warnefors, Henrik Kaessmann
Umfang:14 S.
Fussnoten:Gesehen am 16.08.2018
Titel Quelle:Enthalten in: Genome research
Jahr Quelle:2017
Band/Heft Quelle:27(2017), S. 1461-1474
ISSN Quelle:1549-5469
Abstract:Gene duplications generate genomic raw material that allows the emergence of novel functions, likely facilitating adaptive evolutionary innovations. However, global assessments of the functional and evolutionary relevance of duplicate genes in mammals were until recently limited by the lack of appropriate comparative data. Here we report a large-scale study of the expression evolution of DNA-based functional gene duplicates in three major mammalian lineages (placental mammals, marsupials, egg-laying monotremes) and birds, on the basis of RNA sequencing (RNA-seq) data from nine species and eight organs. We observe dynamic changes in tissue expression preference of paralogs with different duplication ages, suggesting differential contribution of paralogs to specific organ functions during vertebrate evolution. Specifically, we show that paralogs that emerged in the common ancestor of bony vertebrates are enriched for genes with brain-specific expression and provide evidence fordifferential forces underlying the preferential emergence of young testis- and liver-specific expressed genes. Further analyses uncovered that the overall spatial expression profiles of gene families tend to be conserved, with several exceptions of pronounced tissue specificity shifts among lineage-specific gene family expansions. Finally, we trace new lineage-specific genes that may have contributed to the specific biology of mammalian organs, including the little-studied placenta. Overall, our study provides novel and taxonomically broad evidence for the differential contribution of duplicate genes to tissue-specific transcriptomes and for their importance for the phenotypic evolution of vertebrates.
DOI:doi:10.1101/gr.215566.116
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1101/gr.215566.116
 Verlag: http://genome.cshlp.org/content/early/2017/07/25/gr.215566.116
 DOI: https://doi.org/10.1101/gr.215566.116
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1580122027
Verknüpfungen:→ Zeitschrift

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